PAHs and Cancer: Planning a Study in the Slovak Republic

多环芳烃与癌症：计划在斯洛伐克共和国进行一项研究

• 批准号: 6650458
• 负责人: KENNETH A MUNDT
• 金额: $ 7.1万
• 依托单位: APPLIED EPIDEMIOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-25 至 2004-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6650458
• 关键词: Europe; bladder neoplasm; carbopolycyclic compound; chemical carcinogen; clinical research; data collection methodology /evaluation; environmental exposure; experimental designs; human data; lung neoplasms; neoplasm /cancer epidemiology; occupational hazard

DESCRIPTION (provided by applicant): Developing a comprehensive and realistic plan to study the cancer risks associated with occupational and environmental exposure to polycyclic aromatic hydrocarbons (PAHs) is proposed. Previously untapped quantitative PAH occupational and community-based exposure data have been and continue to be gathered and maintained by government scientists in Kosice, Slovak Republic. Data also include cytogenetic aberration test results on hundreds of exposed and non-exposed volunteers. Although PAHs are considered carcinogenic, the epidemiological literature is inconsistent in regards to which cancer risks are elevated and at what exposure level. There is a deficit of quantitative data on individual PAH congeners and cancer risk. The following Specific Aims are proposed to determine whether the existing data are appropriate to address these key research questions in a well-designed epidemiological study: 1) to evaluate existing demographic, work history, and health information data available on coke plant employees and community members that have been monitored for PAH exposure; 2) to assess existing PAH exposure data including both industrial hygiene measures and community air monitoring results; 3) to establish and document procedures for future follow-up of cohort members for cancer incidence and cause of death, as well as obtaining population reference rate data; and 4) to prepare a comprehensive research plan that identifies, to the extent permitted by the existing data, one or more epidemiological studies of the relationships between individual and mixtures of PAH congeners and risk of cancer of the lung, bladder and other sites. Existing data will be computerized, evaluated for completeness and quality, and assessed for their potential epidemiological research use. Based on this assessment, a research database will be developed as well as a detailed research plan, which will serve as a foundation for additional epidemiological research applications.

描述（由申请人提供）： 建议制定一个全面和现实的计划，研究与多环芳烃（PAHs）的职业和环境暴露的癌症风险。斯洛伐克共和国科希策的政府科学家已经并将继续收集和维护以前未利用的多环芳烃职业和社区接触定量数据。数据还包括对数百名接触和未接触的志愿者进行的细胞遗传学畸变测试结果。虽然多环芳烃被认为是致癌物质，但流行病学文献在哪些癌症风险升高以及暴露水平方面并不一致。关于个别PAH同系物和癌症风险的定量数据不足。提出了以下具体目标，以确定现有数据是否适合在设计良好的流行病学研究中解决这些关键研究问题：1）评价已监测PAH暴露的焦化厂员工和社区成员的现有人口统计学、工作史和健康信息数据; 2）评估现有的PAH暴露数据，包括工业卫生措施和社区空气监测结果; 3）建立和记录程序，以便将来对癌症发病率和死亡原因的队列成员进行后续调查，并获得人口参考率数据;以及4）制定一项全面的研究计划，在现有数据允许的范围内，确定一项或多项关于PAH同系物的个体和混合物与肺癌、膀胱癌和其他部位癌症风险之间关系的流行病学研究。将对现有数据进行计算机处理，评估其完整性和质量，并评估其潜在的流行病学研究用途。根据这一评估，将开发一个研究数据库以及一个详细的研究计划，这将作为进一步流行病学研究应用的基础。