FAILURE TIME METHODS FOR FAMILY DISEASE STUDIES

家庭疾病研究的失败时间方法

基本信息

项目摘要

DESCRIPTION (Applicant's abstract) : The long-term objective of this research is the development of sound methodologies which will facilitate studying the role of both genetic and environmental factors in cardiovascular disease. The short term goal of the proposal is to develop statistical methods for age at onset data from population-based family studies of disease incidence. The methods for such studies must accommodate censoring, semi-parametric modeling and familial correlations. Further development is needed for methods which can model complex dependence structures and methods which can examine the fit of parametric dependence models to data. Accordingly, the specific aims of this proposal are development of: (1) a general strategy for evaluating the fit of parametric dependence models for familial clustering of ages at disease-onset; (2) a computationally simple method for genetic linkage analysis of age at onset data; (3) application and illustration of recently developed additive frailty models for complex familial dependence structures. Method (1) will be applied to a family study of cardiovascular disease and a twin study of appendectomy. Method (2) will be applied to ongoing genetic studies conducted at UCSF. Method (3) will be applied to a family study of coronary heart disease in Western Australia. Well-documented, user-friendly programs will be developed and made publicly available.
描述(申请人摘要):本研究的长期目标

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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DAVID V. GLIDDEN其他文献

DAVID V. GLIDDEN的其他文献

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{{ truncateString('DAVID V. GLIDDEN', 18)}}的其他基金

Data Management and Biostatistical Analysis Core
数据管理和生物统计分析核心
  • 批准号:
    10215460
  • 财政年份:
    2020
  • 资助金额:
    $ 13.85万
  • 项目类别:
Data Management and Biostatistical Analysis Core
数据管理和生物统计分析核心
  • 批准号:
    10454923
  • 财政年份:
    2020
  • 资助金额:
    $ 13.85万
  • 项目类别:
Data Management and Biostatistical Analysis Core
数据管理和生物统计分析核心
  • 批准号:
    10669176
  • 财政年份:
    2020
  • 资助金额:
    $ 13.85万
  • 项目类别:
Statistical methods for clinical trials of novel PrEP agents
新型 PrEP 药物临床试验的统计方法
  • 批准号:
    10241934
  • 财政年份:
    2018
  • 资助金额:
    $ 13.85万
  • 项目类别:
Statistical methods for clinical trials of novel PrEP agents
新型 PrEP 药物临床试验的统计方法
  • 批准号:
    9790943
  • 财政年份:
    2018
  • 资助金额:
    $ 13.85万
  • 项目类别:
Chemoprophylaxis for HIV Prevention: Analysis of Bone and Metabolic Effects
预防艾滋病毒的化学预防:骨和代谢影响分析
  • 批准号:
    8992519
  • 财政年份:
    2015
  • 资助金额:
    $ 13.85万
  • 项目类别:
FAILURE TIME METHODS FOR FAMILY DISEASE STUDIES
家庭疾病研究的失败时间方法
  • 批准号:
    6166132
  • 财政年份:
    2001
  • 资助金额:
    $ 13.85万
  • 项目类别:
FAILURE TIME METHODS FOR FAMILY DISEASE STUDIES
家庭疾病研究的失败时间方法
  • 批准号:
    6537859
  • 财政年份:
    2001
  • 资助金额:
    $ 13.85万
  • 项目类别:
Data Management and Biostatistical Analysis Core
数据管理和生物统计分析核心
  • 批准号:
    10084690
  • 财政年份:
  • 资助金额:
    $ 13.85万
  • 项目类别:
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