FAILURE TIME METHODS FOR FAMILY DISEASE STUDIES
家庭疾病研究的失败时间方法
基本信息
- 批准号:6638681
- 负责人:
- 金额:$ 13.85万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-04-01 至 2006-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (Applicant's abstract) : The long-term objective of this research
is the development of sound methodologies which will facilitate studying the
role of both genetic and environmental factors in cardiovascular disease. The
short term goal of the proposal is to develop statistical methods for age at
onset data from population-based family studies of disease incidence. The
methods for such studies must accommodate censoring, semi-parametric modeling
and familial correlations. Further development is needed for methods which can
model complex dependence structures and methods which can examine the fit of
parametric dependence models to data. Accordingly, the specific aims of this
proposal are development of: (1) a general strategy for evaluating the fit of
parametric dependence models for familial clustering of ages at disease-onset;
(2) a computationally simple method for genetic linkage analysis of age at
onset data; (3) application and illustration of recently developed additive
frailty models for complex familial dependence structures. Method (1) will be
applied to a family study of cardiovascular disease and a twin study of
appendectomy. Method (2) will be applied to ongoing genetic studies conducted
at UCSF. Method (3) will be applied to a family study of coronary heart disease
in Western Australia. Well-documented, user-friendly programs will be developed
and made publicly available.
描述(申请人摘要):本研究的长期目标
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DAVID V. GLIDDEN其他文献
DAVID V. GLIDDEN的其他文献
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{{ truncateString('DAVID V. GLIDDEN', 18)}}的其他基金
Data Management and Biostatistical Analysis Core
数据管理和生物统计分析核心
- 批准号:
10215460 - 财政年份:2020
- 资助金额:
$ 13.85万 - 项目类别:
Data Management and Biostatistical Analysis Core
数据管理和生物统计分析核心
- 批准号:
10454923 - 财政年份:2020
- 资助金额:
$ 13.85万 - 项目类别:
Data Management and Biostatistical Analysis Core
数据管理和生物统计分析核心
- 批准号:
10669176 - 财政年份:2020
- 资助金额:
$ 13.85万 - 项目类别:
Statistical methods for clinical trials of novel PrEP agents
新型 PrEP 药物临床试验的统计方法
- 批准号:
10241934 - 财政年份:2018
- 资助金额:
$ 13.85万 - 项目类别:
Statistical methods for clinical trials of novel PrEP agents
新型 PrEP 药物临床试验的统计方法
- 批准号:
9790943 - 财政年份:2018
- 资助金额:
$ 13.85万 - 项目类别:
Chemoprophylaxis for HIV Prevention: Analysis of Bone and Metabolic Effects
预防艾滋病毒的化学预防:骨和代谢影响分析
- 批准号:
8992519 - 财政年份:2015
- 资助金额:
$ 13.85万 - 项目类别:
FAILURE TIME METHODS FOR FAMILY DISEASE STUDIES
家庭疾病研究的失败时间方法
- 批准号:
6166132 - 财政年份:2001
- 资助金额:
$ 13.85万 - 项目类别:
FAILURE TIME METHODS FOR FAMILY DISEASE STUDIES
家庭疾病研究的失败时间方法
- 批准号:
6537859 - 财政年份:2001
- 资助金额:
$ 13.85万 - 项目类别: