NEW MEDIATORS OF CLINICAL LUNG MATURATION

描述：(改编自《调查者摘要》)：胎羊将 暴露于羊膜内毒素，最小有效剂量确定为 以及长期低剂量暴露的影响。随之而来的是， 内毒素的作用将通过将刺激定向到 羊膜腔、体循环、胃肠道或肺部。全 在子宫中暴露的羔羊将被早产并进行指标评估 羊膜腔炎症、肺功能和肺生化指标的关系 成熟的。候选调解人，通过评估胎儿确定 对内毒素的反应，将测试它们诱导胎儿的能力 反应和肺成熟。

DESCRIPTION: (Adapted from the Investigator's Abstract): Fetal sheep will be exposed to intraamniotic endotoxin and the minimal effective dose determined as well as the effects of prolonged low dose exposure. Subsequently, the route of the effects of endotoxin will be evaluated by targeting the stimulus to the amniotic cavity, the systemic circulation, the GI tract, or the lungs. All lambs exposed in utero will be delivered preterm and evaluated for indicators of amniotic space inflammation, lung function, and lung biochemical indicators of maturation. Candidate mediators, identified by evaluating the fetal responses to endotoxin, will be tested for their ability to induce fetal responses and lung maturation.