Mechanisms of Ion Channel Dysfunction in Hereditary and Acquired Neuropathies

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Nerve function is dependent on ion channels, which provide the basis for neurotransmission. Inherited or acquired abnormalities in ion channel function are important in diseases including epilepsy, pain disorders, neuromuscular diseases and toxic neuropathy. This project will use a combination of techniques to study mechanisms underlying nerve dysfunction to compare genetic nerve problems and acquired nerve damage to understand how damage occurs and develop new therapies and diagnostic tests.