Mechanisms of Ion Channel Dysfunction in Hereditary and Acquired Neuropathies

遗传性和获得性神经病中离子通道功能障碍的机制

• 批准号: nhmrc : 1016446
• 负责人: Dr Susanna Park
• 金额: $ 27万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-ion-channel-acquired-neuropathies/109778
• 关键词: Mechanisms; Ion; Channel; Dysfunction; Hereditary

Nerve function is dependent on ion channels, which provide the basis for neurotransmission. Inherited or acquired abnormalities in ion channel function are important in diseases including epilepsy, pain disorders, neuromuscular diseases and toxic neuropathy. This project will use a combination of techniques to study mechanisms underlying nerve dysfunction to compare genetic nerve problems and acquired nerve damage to understand how damage occurs and develop new therapies and diagnostic tests.

神经功能依赖于离子通道，离子通道为神经传递提供基础。遗传性或获得性离子通道功能异常在癫痫、疼痛障碍、神经肌肉疾病和中毒性神经病等疾病中非常重要。该项目将使用多种技术研究神经功能障碍的潜在机制，比较遗传神经问题和获得性神经损伤，了解损伤是如何发生的，并开发新的治疗方法和诊断测试。