2003 FASEB Summer Conference on Lysophospholipids

描述（由申请人提供）：本申请申请为“生物学和疾病中的溶磷脂和相关脂质”会议提供部分资金，该会议将于2003年6月28日至7月3日在美国FASEB主持下的斯诺mass会议中心（斯诺mass， Colorado）举行。本次会议是2000年召开的上一届会议的延续，该会议对这一快速发展的领域产生了重大影响，并被与会者评为优秀。没有其他关于这一主题的会议。由于这是唯一一次关于这一主题的国际会议，它填补了该领域发展的重要需要。溶血磷脂，包括溶血磷脂酸（LPA）和鞘磷脂1-磷酸（S1P），是具有生长因子样作用的脂质介质，因其参与心血管（血管生成、心脏发育、动脉粥样硬化）、（自身）免疫疾病和癌症的病理而成为药物发现的新靶点。LPA、S1P和相关脂质的蛋白作用包括介导细胞增殖、分化、存活和恶性转化。自上次会议以来，《科学》杂志和《自然》杂志分别发表了四篇和三篇文章，报道了与这些溶血磷脂有关的发现。会议将介绍溶血磷脂的分子生物学、生物化学和（病理）生理作用机制的当代观点，以及它们的合成和代谢失活，重点是治疗相关性。将选出大约150名参与者。邀请的演讲者将是最近取得重大成就的人士。会议的一个新颖方面将是一个特别的圆桌会议，讨论未来的趋势和不同背景的研究人员进入该领域的合作。将积极邀请妇女和少数民族的参与，并将寻求8名青年科学家（学生和博士后）的旅行奖励。会议将重点讨论：1)产生这些介质的酶机制，2)脂质磷酸酶，3)LPA和S1P受体，4)信号转导，5)免疫反应的溶脂调节，6)血管生物学中的溶脂，以及7)溶脂在癌症诊断和治疗中的作用。会议应提供这一迅速发展领域的当代观点，并允许对未来方向进行评价，以及对最近的研究进行批判性审查。

DESCRIPTION (provided by applicant): This application requests partial funding for a conference entitled "Lysolphospholipids and Related Lipids in Biology and Diseases" which will be held at the Snowmass Conference Center (Snowmass, Colorado) between June 28-July 3, 2003 under the auspices of FASEB. This conference is a continuation of a previous conference held in 2000 that had a major impact on this rapidly developing field and was rated excellent by the attendees. There are no other theme conferences on the topic. Because it is the only international theme meeting on this subject, it fills an important need for the development of the field. Lysolphospholipids, including lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are lipid mediators with growth factor-like actions that are emerging targets of drug discovery due to their involvement in the pathologies of cardiovascular (angiogenesis, heart development, atherosclerosis), (auto)immune diseases and cancer. The protean roles of LPA, S1P, and related lipids include mediation of cellular proliferation, differentiation, survival, and malignant transformation. Since the last conference, four articles appeared in Science magazine and three in Nature reporting on discoveries related to these lysophospholipids. The conference will present a contemporary view of molecular biological, biochemical, and (patho)physiological mechanisms of action of lysophospholipids as well as their synthesis and metabolic inactivation with a focus on therapeutic correlations. Approximately 150 participants will be chosen. Invited speakers will be persons with significant recent achievements. A novel aspect of the conference will be a special round table discussion about future trends and cooperation among investigators with different backgrounds entering the field. Participation of women and minorities will be vigorously solicited and travel awards for 8 junior scientist (students and post docs) will be sought. There will be sessions focused on 1) Enzymatic mechanisms generating these mediators, 2) Lipid phosphate phosphatases, 3) LPA and S1P receptors, 4) Signal transduction, 5) Lysolipid regulation of the immune response, 6) Lysolipids in vascular biology, and 7) Lysolipids in the diagnosis and management of cancer. The conference should provide a contemporary perspective of this rapidly moving field and allow the evaluation of future directions, as well as critical review of recent research.