Mechanisms of Immunologic Tolerance and Its Breakdown

描述(由申请人提供)：了解免疫耐受的途径及其在自身免疫中崩溃的机制对于开发未来治疗各种自身免疫性疾病的方法至关重要，如糖尿病和多发性硬化症。需要开发新的方法来治疗导致免疫靶细胞破坏的自身免疫性疾病。这次Keystone会议的重点是了解耐受性及其崩溃，并弥合基础、临床前和临床研究之间的差距(联合主席将他们的整个职业生涯都致力于了解免疫耐受性和自身免疫，包括新的治疗方法)。因此，几位演讲者(和研讨会主席)将强烈关注基础研究，而其他人将专注于糖尿病、多发性硬化症、炎症性肠病、葡萄膜炎和狼疮。一个主要主题将是潜在的容忍途径，以及它们是如何被颠覆的。最后，会议将专门讨论新的模式和疗法，并将增加一个特别的临床试验会议。一个新颖的特点是在宴会上向雷·欧文博士和休·麦克德维特博士颁发终身成就奖。会议(暂定)将包括耐受性和淋巴系统稳态的发展、自身免疫的遗传学、免疫抑制、模型系统和自身免疫性疾病的新疗法，重点是原则证明和生物技术，以及临床试验结果。会议的目标是：提供对免疫耐受机制及其崩溃的了解；向观众介绍自身免疫模型和临床试验的最新情况；以及促进来自全球各地的基础和临床科学家以及工业界研发科学家之间的互动，以合作应对这一领域的挑战。

DESCRIPTION (provided by applicant): An understanding of the pathways of immunologic tolerance and the mechanisms of its breakdown in autoimmunity are critical to developing future therapies for a variety of autoimmune disorders, such as diabetes and multiple sclerosis. Novel approaches need to be developed for the treatment of the autoimmune disorders that lead to immune target cell destruction. This Keystone meeting is centered at understanding tolerance and its breakdown and bridging the gap between basic, pre-clinical and clinical studies (the co-chairs have devoted their entire careers to understanding immune tolerance and autoimmunity, including novel therapies). Thus, several speakers (and workshop chairs) will be strongly oriented towards basic studies, while others will focus on diabetes, multiple sclerosis, inflammatory bowel disease, uveitis, and lupus. A major theme will be the underlying tolerance pathways, as well as how they are subverted. Finally, sessions will be devoted to new models and therapies, and a special clinical trials session will be added. A novel feature is the presentation of Lifetime Achievement Awards at the banquet to Drs. Ray Owen and Hugh McDevitt. Sessions (tentative) to be covered include development of the tolerance and lymphoid homeostasis, genetics of autoimmunity, immune suppression, model systems and new therapies for autoimmune diseases, with an emphasis on proof of principle and biotechnology, and clinical trial results. The goals of the meeting are: To provide an understanding of the mechanisms of immune tolerance and its breakdown;To update the audience on autoimmune models and clinical trials; andTo stimulate interactions between basic and clinical scientists, as well as R & D scientists in industry, from around the globe to collaborate to respond to the challenges in this area.