THE SKIN AND ITS CELLS

皮肤及其细胞

• 批准号: 6652669
• 负责人: GIAN-PAOLO DOTTO
• 金额: $ 0.4万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6652669
• 关键词: animal tissue; carcinogenesis; cell growth regulation; epithelium; homeostasis; human tissue; keratinocyte; mammary epithelium; melanocyte; skin; travel; workshop

This workshop is designed to foster interactions between leaders in the field of skin cell biology and researchers with a background in other fields, especially molecular biology and genetics, and interested in applying their knowledge to complex biological systems such as control of epithelial tissue homeostasis and carcinogenesis. The workshop will consist both of theoretical lectures by leading experts in the field and practical hands-on sessions on the cultivation and use of primary cultures of skin cells of various types. The theoretical lectures will include development of the skin; keratinocyte and melanocyte growth/differentiation control; angiogenesis; mammary gland biology; the immune function of the skin; skin as vehicle for gene therapy. Practical topics will cover culture of primary human and mouse keratinocytes, melanocytes, dermal fibroblasts, endothelial cells, mammary epithelial cells; organotypical cultures; gene transfer techniques and skin reconstitution assays. This workshop was already offered once before, in October 1998, and was very well received. Because of this success, we will maintain the same format for the workshop that we are now proposing. The same list of outstanding scientists that participated as speakers last year have tentatively agreed to again participate this year. They include H. Baden, Harvard; V. Band, New England Medical Center; G. Barsh, Stanford; C. Brisken, Whitehead; R. Burgeson, Harvard; C. Daniel, UCSF; M. Detmar, Harvard; R. Halaban, Yale, T. Kupper, Harvard; N. Parenteau, Organogenesis; J. Parrish, Harvard; J. Rheinwald, Harvard; D. Roop, Baylor; K. Stenn, Johnson and Johnson; J. Sundberg, Jackson Labs; and L. Taichman, SUNY.

该研讨会旨在促进皮肤细胞生物学领域的领导者与具有其他领域背景的研究人员之间的互动，特别是分子生物学和遗传学，并有兴趣将他们的知识应用于复杂的生物系统，如上皮组织稳态控制和致癌作用。 该研讨会将包括该领域领先专家的理论讲座和关于各种类型皮肤细胞原代培养物的培养和使用的实践动手课程。 理论讲座将包括皮肤的发育;角质细胞和黑色素细胞的生长/分化控制;血管生成;乳腺生物学;皮肤的免疫功能;皮肤作为基因治疗的载体。 实践主题将涵盖原代人类和小鼠角质形成细胞，黑色素细胞，真皮成纤维细胞，内皮细胞，乳腺上皮细胞的培养;器官型培养;基因转移技术和皮肤重建测定。1998年10月曾举办过一次这一讲习班，反响很好。 由于这一成功，我们将保持我们现在提议的研讨会的同样形式。 去年作为演讲者参加的杰出科学家名单已初步同意今年再次参加。 包括H。巴登，哈佛; V.班德，新英格兰医学中心; G. Barsh，斯坦福大学; Brisken，Whitehead; R. Burgeson，哈佛; C.丹尼尔，加州大学旧金山分校; M. Detmar，哈佛; R. Halaban，Yale，T. Kupper，哈佛; N. Parenteau，Organogenesis; J. Parrish，哈佛; J. Rheinwald，哈佛; D. Roop，Baylor; K. Stenn，约翰逊和约翰逊; J. Sundberg，杰克逊实验室;和L. Taichman，纽约州立大学。