THE SKIN AND ITS CELLS

本次研讨会旨在促进皮肤细胞生物学领域的领导者和具有其他领域背景的研究人员之间的互动，特别是分子生物学和遗传学，并有兴趣将他们的知识应用于复杂的生物系统，如上皮组织稳态控制和致癌作用。研讨会将包括由该领域领先专家的理论讲座和关于培养和使用各种类型皮肤细胞原代培养的实际操作环节。理论讲座将包括皮肤的发育；角质细胞和黑素细胞生长/分化控制；血管生成;乳腺生物学；免疫：皮肤的免疫功能；皮肤作为基因治疗的载体。实践课题将涵盖人类和小鼠原代角质形成细胞、黑色素细胞、真皮成纤维细胞、内皮细胞、乳腺上皮细胞的培养；organotypical文化;基因转移技术和皮肤重建分析。这个讲习班在1998年10月已经举办过一次，受到了很好的欢迎。由于这一成功，我们将为我们现在提议的研讨会保持相同的形式。去年作为演讲人参加的杰出科学家名单今年也暂定再次参加。他们包括哈佛大学的H. Baden；V. Band，新英格兰医学中心；G. Barsh，斯坦福大学；C.布里斯肯，怀特黑德；R. Burgeson，哈佛；C.丹尼尔，加州大学旧金山分校；德马尔，哈佛大学；R. Halaban，耶鲁，T. Kupper，哈佛；N. Parenteau，器官发生；J. Parrish，哈佛；哈佛大学J. Rheinwald；贝勒大学D.鲁普；K. Stenn, Johnson & Johnson；J.桑德伯格，杰克逊实验室；和L. Taichman，纽约州立大学。

This workshop is designed to foster interactions between leaders in the field of skin cell biology and researchers with a background in other fields, especially molecular biology and genetics, and interested in applying their knowledge to complex biological systems such as control of epithelial tissue homeostasis and carcinogenesis. The workshop will consist both of theoretical lectures by leading experts in the field and practical hands-on sessions on the cultivation and use of primary cultures of skin cells of various types. The theoretical lectures will include development of the skin; keratinocyte and melanocyte growth/differentiation control; angiogenesis; mammary gland biology; the immune function of the skin; skin as vehicle for gene therapy. Practical topics will cover culture of primary human and mouse keratinocytes, melanocytes, dermal fibroblasts, endothelial cells, mammary epithelial cells; organotypical cultures; gene transfer techniques and skin reconstitution assays. This workshop was already offered once before, in October 1998, and was very well received. Because of this success, we will maintain the same format for the workshop that we are now proposing. The same list of outstanding scientists that participated as speakers last year have tentatively agreed to again participate this year. They include H. Baden, Harvard; V. Band, New England Medical Center; G. Barsh, Stanford; C. Brisken, Whitehead; R. Burgeson, Harvard; C. Daniel, UCSF; M. Detmar, Harvard; R. Halaban, Yale, T. Kupper, Harvard; N. Parenteau, Organogenesis; J. Parrish, Harvard; J. Rheinwald, Harvard; D. Roop, Baylor; K. Stenn, Johnson and Johnson; J. Sundberg, Jackson Labs; and L. Taichman, SUNY.