Indole Analogs as Novel Appetite Suppressants

描述(申请人提供)：肥胖在美国和全世界影响着数百万人，这种疾病给我们的社会带来了巨大的健康和经济后果。现有的治疗方法显示出有限的疗效，可能会有令人不安的副作用，而且往往需要长期治疗。发现一种治疗肥胖症的新方法将具有非常可观的科学和商业价值。我们已经发现了一种吲哚衍生物，它具有令人鼓舞的药理作用，可以作为潜在的食欲抑制药。在第一阶段，我们建议合成这种活性先导化合物的精心挑选的类似物。这些化合物的药理作用将在体外和体内进行评估。从这个项目中，我们的具体目标是发现一个或多个吲哚类似物在动物模型中显示出与现有疗法相当的食欲抑制效果。这一结果将有力地支持在第二阶段继续进行下去。该项目的长期目标是发现新的、改进的肥胖症治疗方法。

DESCRIPTION (provided by applicant): Obesity affects millions of people in the U.S. and worldwide, and this disease has enormous health and economic consequences for our society. Existing treatments show limited efficacy, can possess troubling side effects, and often require long-term therapy. Discovery of a new treatment for obesity would have very considerable scientific and commercial value. We have discovered an indole derivative possessing an encouraging pharmacological profile as a potential appetite suppressant. In Phase One, we propose to synthesize carefully selected analogs of this active lead compound. The pharmacology of these compounds will be evaluated both in vitro and in vivo. From this project we specifically aim to discover one or more indole analogs showing efficacy in an animal model for appetite suppression comparable to that of established therapies. Such a result will strongly support continuation in Phase Two. The long-term goal of this project is to discover new, improved treatments for obesity.