Remote Telemetry for Neural Recording and Stimulation

描述(由申请人提供)：该项目的目标是创建微型、低功率神经信号记录和刺激系统，该系统可以通过短距离(&lt；10m)遥测控制，用于神经心理学实验。这些系统将被集成到头戴式组件中，并为小到小鼠和大鼠的动物提供多达128个细胞外电极的不受限制的记录和刺激接口。这些系统将包括最近开发的VLSI神经信号放大器和刺激组件，以及商用的现成模数转换器、可编程逻辑和遥测组件。在该计划的第一阶段，我们将研究三种不同遥测模式的可行性：(1)红外串行数据，(2)900 MHz和2.4 GHz ISM频段的频移键控(FSK)调制RF，(3)3.1 GHz至10.6 GHz UWB通信频段的超宽带(UWB)调制RF。该阶段将包括对这些遥测模式的商用部件进行参数测试，并对原型系统进行测试，以调查遥测性能和对神经记录的干扰。在该计划的第二阶段，我们将选择最好的遥测模块，并开发最终的头盔系统和所有外部支持硬件和软件，以便在神经生理学实验中使用这些系统。这些外部组件将包括遥测基站和用于数据采集和模拟控制的灵活数字I/O接口，以及用于控制系统配置的图形用户界面软件。

DESCRIPTION (provided by applicant): The goal of this program is to create miniature, low-power neural signal recording and stimulation systems that can be controlled by short range (<10m) telemetry for neuropsychological experiments. These systems will be integrated into head-mounted packages and provide untethered recording and stimulation interfaces for up to 128 extracellular electrodes for animals as small as mice and rats. The systems will consist of recently developed VLSI neural signal amplifier and stimulation components, and commercial, off-the-shelf analog-to-digital converters, programmable logic, and telemetry components. In Phase I of this program, we will investigate the feasibility of 3 different telemetry modes: (1) Infrared serial data, (2) Frequency Shift Keying (FSK) modulated RF in the 900 MHz and 2.4GHz ISM bands, (3) Ultra-Wide Band (UWB) modulated RF in the 3.1GHz to 10.6GHz UWB communications band. This phase will include parametric testing of commercially available parts for these telemetry modes and testing of prototype systems to investigate telemetry performance and interference with neural recording. In Phase II of this program, we will select the best telemetry modules and develop the final head-mounted systems and all of the external support hardware and software for using these systems in neurophysiological experiments. These external components will include the telemetry base stations and a flexible digital I/O interface for data acquisition and stimulation control along with Graphical User Interface software to control the system configuration.