Carbon Antioxidants To Prevent Atherosclerosis

碳抗氧化剂预防动脉粥样硬化

• 批准号: 6643277
• 负责人: MICHAEL D DIENER
• 金额: $ 10万
• 依托单位: TDA RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6643277
• 关键词: antioxidants; atherosclerosis; carbon; cardiovascular disorder prevention; chemoprevention; copper; drug screening /evaluation; free radical oxygen; lipoxygenase; low density lipoprotein; myeloperoxidase; oxidation; peroxynitrites

DESCRIPTION (provided by applicant): Oxidation of low density lipoprotein (LDL) has been demonstrated to be a crucial early step in the process of arterial atheroma formation. As the atheroma grows and advances in development, the risk of death from myocardial infarction (MI) and stroke increases. It has therefore been proposed that supplemental antioxidants, which protect the LDL, should have therapeutic values against what is the leading cause of death in the United States. While copious in vitro studies have demonstrated that everything from vitamins to grape juice protects LDL from oxidation, in vivo studies using natural antioxidants with humans are less conclusive. There are needs for both a higher standard for in vitro testing and new antioxidant molecules. This project will study whether carbon-based antioxidants can extend their success to LDL protection and confer their benefits in vivo for retarding atherosclerosis.

描述（由申请人提供）：低密度脂蛋白（LDL）的氧化已被证明是动脉粥样硬化形成过程中的关键早期步骤。随着动脉粥样硬化的生长和发展，心肌梗死（MI）和中风的死亡风险增加。因此，有人提出，补充抗氧化剂，保护低密度脂蛋白，应该有治疗价值，对什么是美国的主要死因。虽然大量的体外研究已经证明，从维生素到葡萄汁的所有东西都可以保护LDL免受氧化，但使用天然抗氧化剂对人体进行的体内研究并不那么确定。需要更高的体外测试标准和新的抗氧化剂分子。该项目将研究碳基抗氧化剂是否可以将其成功扩展到LDL保护，并在体内赋予其延缓动脉粥样硬化的益处。