Occupational Physical Activity and Circulatory Diseases

职业体力活动与循环系统疾病

• 批准号: 6561552
• 负责人: NIKLAS KRAUSE
• 金额: $ 36.23万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6561552
• 关键词: Scandinavian; atherosclerosis; behavioral /social science research tag; bioenergetics; body physical activity; cardiovascular disorder risk; clinical research; human data; longitudinal human study; male; myocardial ischemia /hypoxia; occupational hazard; occupational health /safety; peripheral blood vessel disorder

DESCRIPTION (provided by applicant): Low levels of physical activity have been identified as a major risk factor for cardiovascular disease. However, the evidence for this observation is primarily based on leisure time physical activity. The literature regarding occupational physical activity is controversial. The long-term health effects of different levels of energy expenditure and of different types of activity at work are unknown for most circulatory diseases. However, recent epidemiological research has shown a strong association between prolonged standing at work and hospitalization due to varicose veins, 4-year progression of carotid atherosclerosis, all-cause mortality, and a trend for cardiovascular mortality. The aim of the proposed research is to determine the long-term health effects of different types and levels of occupational physical activity on chronic circulatory diseases. This will be accomplished by an 11-year follow-up of 2682 middle-aged men enrolled in the population-based Kuopio Ischemic Heart Disease Risk Factor Study (KIHD). The KIHD study has the most comprehensive set of biological, behavioral, social, and psychological risk factors of any study, allowing for the control of virtually all known possible confounders. For the first time, the impact of occupational physical activity will be evaluated prospectively on 11-year progression of carotid atherosclerosis and a wide range of specific circulatory diseases, including myocardial infarction, stroke, intermittent claudicating, hypertension, thrombophlebitis, and pulmonary embolism. Specifically, the following questions will be addressed: 1) Is the level of daily energy expenditure during work activities associated with circulatory disease and death? 2) Is the ratio of static/dynamic work predictive of morbidity and mortality? 3) Is a predominantly standing working position a risk factor for arteriovascular and venous diseases? 4) Is the impact of occupational physical activity on persons with existing is chemic heart disease or peripheral vascular disease different from the impact on healthy individuals? The long-term goals of this project are to yield useful information for (1) the primary prevention of chronic diseases of the circulatory system, associated disability, and premature death in the aging working population, and (2) the development of evidence-based recommendations for the optimal balance between static and dynamic work, working postures, and overall levels of occupational and leisure time physical activity, for both healthy people and those diagnosed with cardiovascular disease.

描述（由申请人提供）：低水平的体力活动已被确定为心血管疾病的主要风险因素。然而，这一观察结果的证据主要是基于休闲时间的身体活动。关于职业体力活动的文献是有争议的。对于大多数循环系统疾病来说，不同水平的能量消耗和不同类型的工作活动对健康的长期影响是未知的。然而，最近的流行病学研究表明，长时间站立工作与静脉曲张住院、颈动脉粥样硬化4年进展、全因死亡率和心血管死亡率趋势之间存在密切联系。 这项研究的目的是确定不同类型和水平的职业体力活动对慢性循环系统疾病的长期健康影响。这将通过对2682名参加基于人群的库奥皮奥缺血性心脏病风险因素研究（KIHD）的中年男性进行11年随访来实现。 KIHD研究具有任何研究中最全面的生物学，行为，社会和心理风险因素，允许控制几乎所有已知的可能混杂因素。首次前瞻性评估职业性体力活动对颈动脉粥样硬化和广泛的特定循环系统疾病（包括心肌梗死、中风、间歇性跛行、高血压、血栓性静脉炎和肺栓塞）11年进展的影响。具体而言，将解决以下问题：1）工作活动期间的每日能量消耗水平是否与循环系统疾病和死亡相关？2)静态/动态工作的比率是否能预测发病率和死亡率？3)主要站立的工作姿势是动静脉疾病的危险因素吗？4)职业体力活动对患有化学性心脏病或周围血管疾病的人的影响与对健康人的影响是否不同？ 该项目的长期目标是为以下方面提供有用的信息：（1）老年工作人口中循环系统慢性疾病、相关残疾和过早死亡的初级预防;（2）为静态和动态工作、工作姿势以及职业和休闲时间身体活动的总体水平之间的最佳平衡制定基于证据的建议。对于健康人和那些被诊断患有心血管疾病的人来说。