The Hektoen Institute of Medical Research Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)

Hektoen 医学研究所站点联盟 - HIV/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心（UM2 临床试验可选）

• 批准号: 10709606
• 负责人: Karen Simpson
• 金额: $ 34.09万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709606
• 关键词: AIDS prevention; Academic Medical Centers; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent Medicine Trials Network; Adolescent and Young Adult; Affect; Age; Area; Articulation; Award; Awareness; Black race; Caring; Catchment Area; Chicago; Cities; Clinic; Clinical; Clinical Trials; Collaborations; Communities; Community Health Networks; Community Outreach; Continuity of Patient Care; Contracts; County; Development; Diagnosis; Diagnostic; Education; Epidemic; Event; Foundations; Fumarates; Goals; Grant; HIV; HIV Infections; HIV diagnosis; HIV-infected adolescents; HIV/AIDS; Health; Health education; Health system; Healthcare; High Prevalence; Hispanic; Hospitals; Illinois; Individual; Infection; Infectious Diseases Research; Intervention; Intervention Studies; Laboratories; Leadership; Longitudinal cohort study; Medical Research; Methods; Midwestern United States; Modeling; Participant; Patients; Pediatric Hospitals; Persons; Pharmacy facility; Prevalence; Prevention; Prevention approach; Prevention strategy; Primary Prevention; Productivity; Provider; Public Health; Recording of previous events; Research; Research Project Grants; Research Support; Risk; Safety; Secondary Prevention; Services; Sexual Health; Sexual and Gender Minorities; Sexually Transmitted Diseases; Side; Site; Structure; Tenofovir; Testing; United States; Universities; Vulnerable Populations; Washington; Work; Youth; adolescent substance abuse; combat; community engagement; community organizations; cooking; detention center; emtricitabine; ethnic minority; experience; gender minority group; high risk; implementation intervention; improved; infection rate; innovation; low socioeconomic status; medically underserved; meetings; men who have sex with men; minority communities; multidisciplinary; new technology; operation; pre-exposure prophylaxis; preventive intervention; programs; racial minority; recruit; research study; safety net; sexual minority group; tertiary prevention; virtual

ABSTRACT Cook County Health Despite advances in Human Immunodeficiency Virus (HIV) diagnostics, care, and prevention strategies, infection rates continue to rise across the United States, particularly the medically underserved of low socio- economic status, sexual and gender minority groups, and/or racial/ethnic minority constituency, and/or substance abusing youth. There is an urgent need to reduce the number of new HIV infections among at-risk youth and improvements in numbers across the HIV care continuum. The Adolescent and Young Adult Research (AYAR) at Core Consortium will participate in the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) as it has since 2001. The AYAR consortium will continue to work collaboratively within the ATN structure to assist in the development and implementation of interventional studies that address the ATN scientific priority areas across the HIV/AIDS prevention and treatment continuum among adolescents and young adults (ages 13-24) through primary, secondary, and tertiary prevention approaches. The consortium's HIV experienced, multidisciplinary clinical and community-based staff will be responsible for ATN subject recruitment, retention, and safety in our well-established adolescent HIV care program and consortium network, with the use of innovative methods, to reach the most underserved and highest risk communities of the Chicagoland area. They will continue to improve upon its leadership model with meaningful and sustainable community engagement efforts, targeting high HIV prevalence areas, leveraging local health departments and community partners in promoting and engaging youth in health care and research directed at ending the HIV epidemic. The consortium will maintain and establish new Community Based Organization (CBO) partnerships and conduct community outreach activities in targeted areas within Cook County's high HIV-affected areas and with a focus on sexual minority groups. AYAR will continue to support CBOs via in- person or virtual meetings and events, educational sessions, and sexually transmitted infection (STI) testing. AYAR will continue to maintain an active research Youth Advisory Board (YAB) with regular meetings via in person or virtual means. The consortium will increase sexual health education and awareness of HIV prevention strategies and assist with linkage to care for pre-exposure prophylaxis (PrEP) and HIV care. The AYAR will provide site, laboratory, pharmacy, and community capacities, to support impactful research studies identified by the ATN Executive Committee and Scientific Leadership Group, in collaboration with the Operations and Collaborations Center (OCC). Our investigative team has decades of experience with recruitment, prevention, and care of at-risk youth and large-scale longitudinal cohort studies. This study will capitalize upon productive existing partnerships to articulate the drivers of the ongoing HIV epidemic among the most vulnerable populations in the Chicagoland area in order to identify the most effective, expeditious, and scalable strategies to address this ongoing public health crisis.

库克县卫生局 尽管人类免疫缺陷病毒（艾滋病毒）诊断、护理和预防战略取得了进展， 美国各地的感染率继续上升，特别是医疗服务不足的低社会保障水平人群， 经济地位、性和性别少数群体和/或种族/族裔少数群体，和/或 滥用药物的年轻人迫切需要减少高危人群中新感染艾滋病毒的人数， 艾滋病毒护理连续体的人数增加。青少年和年轻人 核心联盟的研究（AYAR）将参加艾滋病毒/艾滋病青少年医学试验网络 自2001年以来，ATN一直在进行干预。AYAR联盟将继续在 ATN结构，以协助开发和实施针对ATN的干预性研究 青少年艾滋病毒/艾滋病预防和治疗的整个科学优先领域， 青年人（13-24岁）通过初级、二级和三级预防方法。财团的 艾滋病毒经验丰富的多学科临床和社区工作人员将负责ATN受试者 在我们完善的青少年艾滋病毒护理计划和联盟中招募、保留和安全 网络，采用创新的方法，以达到最缺乏服务和最高风险的社区， 芝加哥地区。他们将继续改进其领导模式， 可持续的社区参与努力，以艾滋病毒高流行地区为目标， 各部门和社区合作伙伴促进青年参与保健和研究， 终结艾滋病的流行。联合体将维持和建立新的社区组织 (CBO)伙伴关系，并在库克县的高目标地区开展社区外展活动 受艾滋病毒影响的地区，重点是性少数群体。AYAR将继续通过以下方式支持CBO- 个人或虚拟会议和活动、教育会议和性传播感染（STI）检测。 AYAR将继续保持一个积极的研究青年咨询委员会（YAB），定期举行会议， 人或虚拟的方式。该联盟将增加性健康教育和艾滋病毒的认识 预防战略，并协助联系接触前预防护理和艾滋病毒护理。的 AYAR将提供现场，实验室，药房和社区能力，以支持有影响力的研究 由ATN执行委员会和科学领导小组与 运营与协作中心（OCC）。我们的调查团队拥有数十年的 招募、预防和护理高危青少年以及大规模纵向队列研究。本研究将 利用现有的富有成效的伙伴关系，阐明艾滋病毒流行的驱动因素， 最脆弱的人群在芝加哥地区，以确定最有效，迅速， 和可扩展的战略来解决这一持续的公共卫生危机。