Genetic Regulation of Mating Behavior in C. elegan Males

雄性秀丽隐杆线虫交配行为的遗传调控

基本信息

  • 批准号:
    6801000
  • 负责人:
  • 金额:
    $ 25.03万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-09-15 至 2010-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The goal of this project is to understand how a step in a complex behavior is genetically specified. This fundamental problem will be addressed by studying C. elegans male mating behavior. During mating, the male executes a series of stereotyped sub-behaviors that result in the insertion of his copulatory spicules into his mate and the subsequent transfer of sperm. Although C. elegans male mating behavior consists of many steps, this project will focus on dissecting how the male inserts his spicules into his mate's vulva. Spicule insertion behavior is a simple reflex; however, the male nervous system and musculature must regulate many factors. The neurons and muscles must compute when to initiate the behavior and monitor if the behavioral outcome was successful. If an insertion attempt fails, the circuitry must re-initiate the behavior. If penetration is successful, the circuitry keeps the spicules inserted while the next behavioral step proceeds. Males display spicule insertion behavior only during mating. However, mutations can be generated that will cause males to display this behavior abnormally in the absence of mating cues. One of these mutations disrupts the C. elegans unc-103 gene. Unc-103 is the C. elegans homolog of the human h-erg-encoded voltage-gated delayed rectifying K+ channel. In humans, HERG channels regulate cardiac rhythm. Mutations in h-erg that reduce ion channel function can increase the probability of spontaneous lethal heart arrhythmias, a condition called long QT syndrome. Spicule insertion behavior requires coordination between different neurons and muscles. Mutations in unc-103 disrupt that regulation and result in spontaneous seizures of male-specific muscles that are used for copulation. To understand how unc-103 is used to regulate behavior, this project will identify where unc-103 is acting in the behavioral circuitry of males. The project will also determine the identities of mutations that affect candidate genes that may act with or in parallel to unc-103 to regulate behavior. Additionally, this project will identify components of activating pathways that must be attenuated by unc-103 during periods between mating.
描述(由申请人提供):这个项目的目标是了解如何在一个复杂的行为的一个步骤是遗传指定。这一基本问题将通过研究C.雄性的交配行为在交配过程中,雄性执行一系列刻板的子行为,导致他的交配刺插入他的配偶和随后的精子转移。虽然C.雄性线虫的交配行为包含许多步骤,本计画将着重解剖雄性线虫如何将其骨针插入配偶的阴户。刺的插入行为是一种简单的反射,然而,男性的神经系统和肌肉组织必须调节许多因素。神经元和肌肉必须计算何时启动行为,并监控行为结果是否成功。如果插入尝试失败,则电路必须重新启动行为。如果刺入成功,神经回路会让针状体继续插入,同时进行下一个行为步骤。雄性仅在交配期间显示骨针插入行为。然而,突变可以产生,这将导致男性在没有交配线索的情况下表现出异常的行为。其中一个突变破坏了C。elegans unc-103基因Unc-103是C。人类h-erg编码的电压门控延迟整流K+通道的elegans同源物。在人类中,HERG通道调节心律。降低离子通道功能的h-erg突变会增加自发性致命性心律失常的可能性,这种情况称为长QT综合征。刺的插入行为需要不同神经元和肌肉之间的协调。unc-103的突变破坏了这种调节,导致用于交配的雄性特异性肌肉自发发作。为了了解unc-103是如何用来调节行为的,这个项目将确定unc-103在男性行为回路中的作用。该项目还将确定影响候选基因的突变的身份,这些候选基因可能与unc-103一起或平行作用,以调节行为。此外,该项目将确定在交配期间必须被unc-103减弱的激活途径的组成部分。

项目成果

期刊论文数量(0)
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LUIS RENE GARCIA其他文献

LUIS RENE GARCIA的其他文献

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{{ truncateString('LUIS RENE GARCIA', 18)}}的其他基金

Genetic Regulation of Mating Behavior in C. elegan Males
雄性秀丽隐杆线虫交配行为的遗传调控
  • 批准号:
    6932018
  • 财政年份:
    2003
  • 资助金额:
    $ 25.03万
  • 项目类别:
Genetic Regulation of Mating Behavior in C. elegan Males
雄性秀丽隐杆线虫交配行为的遗传调控
  • 批准号:
    6707739
  • 财政年份:
    2003
  • 资助金额:
    $ 25.03万
  • 项目类别:
Genetic Regulation of Mating Behavior in C. elegan Males
雄性秀丽隐杆线虫交配行为的遗传调控
  • 批准号:
    7113159
  • 财政年份:
    2003
  • 资助金额:
    $ 25.03万
  • 项目类别:
Genetic Regulation of Mating Behavior in C. elegan Males
雄性秀丽隐杆线虫交配行为的遗传调控
  • 批准号:
    7275283
  • 财政年份:
    2003
  • 资助金额:
    $ 25.03万
  • 项目类别:
Genetic Regulation of Mating Behavior in C. elegan Males
雄性秀丽隐杆线虫交配行为的遗传调控
  • 批准号:
    7680101
  • 财政年份:
    2003
  • 资助金额:
    $ 25.03万
  • 项目类别:
Genetic Regulation of Mating Behavior in C. elegan Males
雄性秀丽隐杆线虫交配行为的遗传调控
  • 批准号:
    7487938
  • 财政年份:
    2003
  • 资助金额:
    $ 25.03万
  • 项目类别:
MOLECULAR STUDY OF C ELEGANS MALE MATING BEHAVIOR
线虫雄性交配行为的分子研究
  • 批准号:
    2734354
  • 财政年份:
    1998
  • 资助金额:
    $ 25.03万
  • 项目类别:
MOLECULAR STUDY OF C ELEGANS MALE MATING BEHAVIOR
线虫雄性交配行为的分子研究
  • 批准号:
    2021635
  • 财政年份:
    1997
  • 资助金额:
    $ 25.03万
  • 项目类别:
MOLECULAR STUDY OF C ELEGANS MALE MATING BEHAVIOR
线虫雄性交配行为的分子研究
  • 批准号:
    6018321
  • 财政年份:
    1997
  • 资助金额:
    $ 25.03万
  • 项目类别:

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