A Novel Post-Menopausal Osteoporosis Screening Tool

描述(由申请人提供)： 骨质疏松症对美国人口的影响很大，有超过2500万人受到这种疾病的影响。通常情况下，这种易患退行性疾病每年导致约130万人骨折，成本超过100亿美元。这项修订后的赠款申请将开发和评估一种新的但经济的技术，它有可能被用作一种非侵入性和客观的工具，用于检测绝经后骨质疏松症妇女的脊柱骨折指征。建议的非侵入性技术可以提供有关骨质量的关键信息，以补充传统的DEXA骨密度(BMD)测量。绝经后骨质疏松症技术将利用微型皮肤安装加速度计来捕捉与脚跟撞击诱导的力传播相关的人类肌肉骨骼系统(包括肌肉和松质骨的软组织，在健康骨骼中具有显著的弹性能力)的天然减震器的有效减震能力和其他机械性能(包括脆性)的变化。 文献缺乏关于骨质疏松症如何影响天然减震器的信息。由于我们团队的初步研究已经成功地对另一种类型的退行性肌肉骨骼疾病(即骨关节炎患者)的肌肉骨骼系统的天然减震器进行了量化，因此建议的技术捕获骨质疏松骨骼的减震特性的成功可能性很高。 该技术具有完全无创、客观、简便、快速的特点。这项拟议的研究将侧重于测量有骨折和无骨折的绝经后骨质疏松症的自然减震特性，并补充从骨密度测量中收集的信息。一旦拟议的技术显示出希望，未来的前瞻性研究将允许确定该技术在临床前诊断有骨折风险的个人的有效性。

DESCRIPTION (provided by applicant): Osteoporosis has a significant impact on the United States population, with more than 25 million people affected by the disease. Often times, this predisposed degenerative disease leads to about 1.3 million fractures per year with the costs being in excess of 10 billion dollars. This revised grant application will develop and evaluate a novel and yet economical technique, which has the potential to be used as a non-invasive and objective tool for detecting indications of spine fractures in post-menopausal osteoporotic women. The proposed non-invasive technique can provide critical information about the quality of the bone that can supplement traditional DEXA bone mineral density (BMD) measurements. The post-menopausal osteoporosis technique will utilize miniature skin mounted accelerometers to capture the changes in effective damping capacities and other mechanical properties (including brittleness) of natural shock absorbers of the human musculoskeletal systems (soft tissues including muscles and trabecular bone which has significant elastic capacity in healthy bones), associated with heel strike induced force propagation. The literature lacks information regarding how osteoporosis affects natural shock absorbers. The potential of success for the proposed technique's ability to capture shock absorption properties of osteoporotic bones is high since preliminary studies from our group have successfully quantitated natural shock absorbers of the musculoskeletal system in another type of degenerative musculoskeletal diseases i.e. osteoarthritic patients. The proposed technique is totally non-invasive, objective, simple and quick to administer. The proposed study will focus on measuring natural shock absorption properties of postmenopausal osteoporosis with and without fractures and supplement information gathered from BMD measurements. Once the proposed technique shows promise future prospective study will allow determination of the effectiveness of the technique to diagnose individuals at risk for fracture, pre-clinically.