Functional Bowel Disorders in Chinese Medicine

中医功能性肠病

• 批准号: 6805851
• 负责人: BRIAN M BERMAN
• 金额: $ 10.88万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-22 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6805851
• 关键词: Chinese; acupuncture /acupressure; alternative medicine; biological models; biomarker; chromatography; clinical research; cooperative study; data management; disease /disorder model; drug screening /evaluation; electron microscopy; human subject; hyperalgesia; immunocytochemistry; irritable bowel syndrome; laboratory rat; magnetic resonance imaging; medicinal plants; outcomes research; patient oriented research; pharmacokinetics; polymerase chain reaction

DESCRIPTION (provided by applicant): This application is for a Planning Grant for International Centers for Research on Complementary and Alternative Medicine (PICRC) in response to RFA AT-03-002. The goal of planning phase activities is to begin creation of the Functional Bowel Disorders and Traditional Chinese Medicine Research Group, with the participation of consortium members of three universities, The University of Maryland Center for Integrative Medicine, the Chinese University of Hong Kong, and the University of Illinois at Chicago Program for Collaborative Research in the Pharmaceutical Sciences. The consortium will develop a grant application for an International Center for Research on Complementary and Alternative Medicine (ICRC) to be submitted during the two-year planning phase, which will request funding to support three pilot projects related to irritable bowel syndrome and three cores: a Pharmacologic Core, a Data Management, Analysis, and Coordination Core, and an Administrative Core. The projects to be proposed will include 1) a rat model irritable bowel syndrome treatment trial using acupuncture and herbs, 2) a human pathophysiology pilot study on the effect of TCM on cerebral cortical activation and visceral sensation to rectal distension in IBS patients and non-IBS volunteers, and 3) Phase I and II clinical trials of TCM treatment in diarrhea-type IBS patients. Pilot studies in the animal model, standardization and authentication of the herbal preparation, and the techniques of human rectal distension in the functional MRI environment will be conducted in the planning phase to facilitate the projects to be proposed.

描述（由申请人提供）：本申请是针对RFA AT-03-002的补充和替代医学国际研究中心（PICRC）的规划补助金。计划阶段活动的目标是开始建立功能性肠病和传统中医药研究小组，由三所大学的联盟成员参与，即马里兰州大学中西医结合中心、香港中文大学和伊利诺伊大学芝加哥分校药学科学合作研究计划。该联盟将为国际补充和替代医学研究中心（ICRC）制定一份赠款申请，该申请将在两年规划阶段提交，该申请将要求资助与肠易激综合征相关的三个试点项目和三个核心：药理学核心，数据管理，分析和协调核心以及行政核心。拟开展的项目包括：1）利用针灸和中药治疗肠易激综合征大鼠模型试验; 2）关于中医药对IBS患者和非IBS志愿者直肠扩张时大脑皮层激活和内脏感觉影响的人体病理生理学初步研究;以及3）中医药治疗肠易激综合征患者的I期和II期临床试验。在规划阶段，将进行动物模型、草药制剂的标准化和认证以及在功能性磁共振成像环境中的人类直肠扩张技术的试点研究，以促进提出的项目。