EXERCISE TO IMPROVE HRV IN SUDDEN CARDIAC ARREST

简历(申请人提供)：应聘者？S长期目标是 开发运动处方，改善老年人的身体和心理社会健康 心脏骤停(SCA)幸存者。为了实现这一目标，有重点地 提出了研究型职业发展规划，包括深入研究：1) 心肺运动和代谢试验，2)心脏的测量 自主神经系统功能(心率变异性)，以及3)进展 心率数据的统计分析。这项建议的目的是 确定对幸存者进行运动干预的安全性和可行性 10例使用自动心脏复律除颤器(ICD)的SCA。 其次，检测运动对心脏自主神经功能的影响 (心率变异性(HRV)、健康结果(心率稳定性、一般 与健康相关的生活质量、心理困扰)和主要不良反应 心脏事件(心脏住院、急诊室就诊和心脏死亡率)是 建议。主要成果是实施 运动干预从基线持续到8周。政制事务局局长提出的申索约为 美国每年有30万人死亡，占总死亡人数的40% 由心血管疾病引起的。SCA常发生在医院外 在没有警告的情况下，大多数复苏的受害者在死亡时接受ICD 住院治疗。大约29%的人在最初的 心脏骤停，每年有超过40,000人接受ICD 植入。恶性室性心律失常的发生与发展 SCA的发生部分归因于自主神经系统的失衡 功能。交感神经系统活动增加，并降低 副交感神经活动已被证明会导致更多的脑室 心律不齐。对SCA的保护可以通过以下机制实现 增加副交感神经张力，锻炼是这些疗法之一。锻炼 培训是一种廉价的非药物干预，本质上是 没有负面副作用，几乎对所有人都适用。我的 感兴趣的是确定运动是否会影响心脏副交感神经 神经系统调节，因此传递心脏保护作用， 会不会影响室性心律失常的复发率 休克和心脏死亡率。这项研究的结果有可能 影响未来的锻炼建议和处方、可行性、安全性、 颈内动脉狭窄存活者的生活质量？S。

DESCRIPTION (provided by applicant): The candidate?s long-term goal is to develop exercise prescriptions that improve physical and psychosocial health of survivors of sudden cardiac arrest (SCA). To achieve this goal a focused research career development Plan is proposed, including intensive study of: 1) cardiopulmonary exercise and metabolic testing, 2) measurement of cardiac autonomic nervous system function (heart rate variability), and 3) advanced statistical analysis of heart rate data. The purpose of this proposal is to determine the safety and feasibility of an exercise intervention in survivors (N= 10) of SCA who have automatic internal cardioverter defibrillators (ICDs). Secondarily, testing the impact of exercise on cardiac autonomic function (heart rate variability (HRV), health outcomes (heart rhythm stability, general health related quality of life, psychological distress), and major adverse cardiac events (cardiac hospitalizations, ER visits, and cardiac mortality) is proposed. The primary outcomes are safety and feasibility in implementing the exercise intervention from baseline to 8 weeks. SCA claims approximately 300,000 lives in the US per year, representing 40 percent of the total deaths resulting from cardiovascular disease. SCA often occurs outside the hospital without warning, where most resuscitated victims receive an ICD at the time of hospitalization. Approximately 29 percent of persons survive the initial cardiac arrest, with greater than 40,000 persons/year undergoing ICD implantation. The development of malignant ventricular arrhythmias at the time of SCA has been attributed in part to imbalances in autonomic nervous system function. Increased sympathetic nervous system activity and decreased parasympathetic activity has been shown to result in more ventricular arrhythmias. Protection against SCA may be achieved through mechanisms that increase parasympathetic tone, exercise being one of these therapies. Exercise training is an inexpensive, nonpharmacological intervention that is essentially devoid of negative side effects and virtually available to everyone. My interest is in determining if exercise will affect cardiac parasympathetic nervous system regulation and therefore convey cardioprotective effects that will subsequently influence rates of recurrence of ventricular arrhythmias, ICD shocks, and cardiac mortality. The results of this study have the potential to impact future exercise recommendations and prescriptions, feasibility, safety, and quality of life in SCA survivors with ICD?s.