TOPIC 435 - PHYSIOLOGICAL COMPRESSION THERAPY TO AUGMENT LYMPHATIC FUNCTION AND IMPROVE LYMPHEDEMA RESOLUTION.

主题 435 - 增强淋巴功能并改善淋巴水肿消退的生理压迫疗法。

• 批准号: 10727095
• 负责人: MICHAEL WEILER
• 金额: $ 40万
• 依托单位: LYMPHATECH, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2023-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10727095
• 关键词: TOPIC; 435; PHYSIOLOGICAL; COMPRESSION; THERAPY

LymphaTech seeks to develop a novel lymphatic physiology-based, feedback-controlled intermittent pneumatic compression (IPC) device for the treatment of secondary lymphedema. While compression therapy has been the primary treatment for lymphedema patients for decades, there have been minimal innovations in approaches that leverage compression therapy. In contrast to this, there have been substantial gains in understanding of lymphatic physiology and lymphedema disease progression that have not been realized into innovative approaches to improve compression for lymphedema. This Phase 1 proposal aims to develop a prototype that drastically improves medical compression therapy through the major innovations: 1) the incorporation of dynamic external pressure waveforms with magnitudes and temporal and spatial frequencies that are optimized to enhance lymphatic contraction of the lymphatic pump; 2) realtime monitoring of tissue bioimpedance using novel flexible, wearable sensors to provide feedback of tissue water content to compression protocols for optimization of compression based on patient activity (e.g. sleeping, standing, sitting); and 3) incorporation of LymphaTech’s proprietary compression garment sizing and limb measurement volume technology to further enhance compression efficacy. Optimizing the delivery of lymphatic physiology-based compression waveforms combined with real-time feedback from embedded sensors is expected to dramatically increase the clinical efficacy of IPC for lymphedema patients.

LymphaTech旨在开发一种新型的基于淋巴生理学的反馈控制间歇式气动 加压（IPC）装置用于治疗继发性水肿。虽然压迫疗法是主要的 几十年来，对于水肿患者的治疗，在利用 压迫疗法与此相反，在对淋巴生理学的理解方面已经有了实质性的进展， 水肿疾病进展尚未实现为创新方法，以改善压迫， 水肿该第一阶段提案旨在开发一种原型，大大改善医疗压缩治疗 通过主要的创新：1）将动态外部压力波形与幅度结合， 优化的时间和空间频率以增强淋巴泵的淋巴收缩; 2）实时 使用新颖的柔性、可穿戴传感器来提供组织水反馈的组织生物阻抗监测 根据患者活动（例如，睡眠，站立， 坐姿）;以及3）结合LymphaTech专有的压缩服装尺寸和肢体测量体积 技术，以进一步提高压缩效率。优化基于淋巴生理学的压迫输送 波形与嵌入式传感器的实时反馈相结合，预计将大大提高临床 IPC治疗急性脑水肿的疗效观察