TOPIC 435 - PHYSIOLOGICAL COMPRESSION THERAPY TO AUGMENT LYMPHATIC FUNCTION AND IMPROVE LYMPHEDEMA RESOLUTION.

LymphaTech致力于开发一种基于淋巴生理、反馈控制的新型间歇气动 用于治疗继发性淋巴水肿的压迫(IPC)装置。虽然按压疗法一直是主要的 淋巴水肿患者的治疗几十年来，在利用 按压疗法。与此形成对比的是，在对淋巴生理学和淋巴疾病的了解方面取得了实质性的进展 淋巴水肿病的进展尚未实现为创新的方法，以改善压缩 淋巴浮肿。这个第一阶段的提案旨在开发一种原型，极大地改进医学按压疗法 通过主要的创新：1)结合了具有大小和 时间和空间频率被优化以增强淋巴泵的淋巴收缩；2)实时 使用新型灵活、可穿戴的传感器提供组织水的反馈来监测组织生物阻抗 压缩协议的内容，用于基于患者活动(例如，睡眠，站立， 坐着)；以及3)采用LymphaTech专有的压缩服装尺寸和肢体尺寸 技术进一步增强了压缩效果。基于淋巴生理学的加压方式的优化 波形与嵌入式传感器的实时反馈相结合，有望显著提高临床 IPC对淋巴水肿患者的疗效观察

LymphaTech seeks to develop a novel lymphatic physiology-based, feedback-controlled intermittent pneumatic compression (IPC) device for the treatment of secondary lymphedema. While compression therapy has been the primary treatment for lymphedema patients for decades, there have been minimal innovations in approaches that leverage compression therapy. In contrast to this, there have been substantial gains in understanding of lymphatic physiology and lymphedema disease progression that have not been realized into innovative approaches to improve compression for lymphedema. This Phase 1 proposal aims to develop a prototype that drastically improves medical compression therapy through the major innovations: 1) the incorporation of dynamic external pressure waveforms with magnitudes and temporal and spatial frequencies that are optimized to enhance lymphatic contraction of the lymphatic pump; 2) realtime monitoring of tissue bioimpedance using novel flexible, wearable sensors to provide feedback of tissue water content to compression protocols for optimization of compression based on patient activity (e.g. sleeping, standing, sitting); and 3) incorporation of LymphaTech’s proprietary compression garment sizing and limb measurement volume technology to further enhance compression efficacy. Optimizing the delivery of lymphatic physiology-based compression waveforms combined with real-time feedback from embedded sensors is expected to dramatically increase the clinical efficacy of IPC for lymphedema patients.