Training in Systems Pharmacology and Toxicology (T-SPaT)

系统药理学和毒理学培训 (T-SPaT)

• 批准号: 10714918
• 负责人: Paul L Prather
• 金额: $ 17.4万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714918
• 关键词: Pharmacology and Toxicology; System; Training

PROJECT SUMMARY/ABSTRACT Over the past few decades, our knowledge of the mechanisms by which cells interact with drugs and toxins has exploded due to new molecular analysis techniques and the application of genomic methods. Accordingly, the emphasis of graduate education in the disciplines of pharmacology and toxicology needs to shift from a reductionist view to a systems approach in which doctoral students are comprehensively trained so they can formulate a strategy to solve important biological questions not only at the molecular, cellular, and tissue levels but also at the whole-animal level. Systems pharmacology and toxicology describes a field of study that considers the broad view of drug action. A systems approach using in vivo animal models is necessary to establish efficacy, safety and the pharmacodynamic/pharmacokinetic profile of candidate drugs but there is a shortage of students trained in this area. This Training in Systems Pharmacology and Toxicology (T-SPaT) Program is designed for PhD students in their second year of graduate study pursuing dissertation research projects in the pharmacological sciences. Trainees (2/year for up to 2 years of support) and 33 Program faculty are drawn from the Graduate Program in Interdisciplinary Biomedical Sciences (GPIBS) and the MD/PhD Program. The T-SPaT program will train students to use an in vivo approach to answering relevant questions in pharmacology and toxicology with emphasis on metabolism, drug design, pharmacodynamics, pharmacokinetics, and signaling. The rationale for the T-SPaT program is that this type of training will provide students with a much broader perspective on pharmacology and toxicology that will better prepare them to conduct safe, ethical and rigorous research as leaders of multidisciplinary research teams in the pharmacological sciences. We will integrate T- SPaT into PhD training programs already active at our graduate training sites in the Little Rock area that include faculty/scientists in the Colleges of Medicine, Pharmacy, and Public Health on the UAMS, the Arkansas Children’s Hospital campus, and at the Food and Drug Administration-funded National Center for Toxicological Research. The unique focus of T-SPaT is training with in vivo systems pharmacological and toxicological approaches and concepts. The objective of T-SPaT is to provide in vivo pharmacology and toxicology training that complement the cellular and molecular training that students receive in their home programs. The training program consists of didactic training in pharmacology, toxicology, physiology, pharmacokinetics, metabolism, biostatistics, grant writing, and the Responsible Conduct of Research along with laboratory research using an in vivo model of human disease. The T-SPaT program will also provide strong mentoring, extensive networking, and teaching and leadership opportunities for its trainees through its programmatic activities.

项目摘要/摘要 在过去的几十年中，我们对细胞与药物和毒素相互作用的机制的了解 由于新的分子分析技术和基因组方法的应用而爆炸。根据 强调药理学学科和毒理学学科的研究生教育需要从 还原主义者对一种系统方法进行了全面培训的系统方法，以便他们可以 制定一种策略，不仅在分子，细胞和组织水平上解决重要的生物学问题 而且还处于整个动物级别。系统药理学和毒理学描述了考虑的研究领域 毒品作用的广泛观点。使用体内动物模型的系统方法对于建立有效性是必要的 候选药物的安全性和药效/药代动力学特征，但学生短缺 在这个地区训练。系统药理学和毒理学（T-SPAT）计划的这种培训是为 博士生在研究生学习的第二年，从事论文研究项目 药理学科学。学员（最多2年的2年支持）和33个课程教师来自 跨学科生物医学科学（GPIB）和MD/PHD计划的研究生课程。 T-ppat 计划将培训学生使用体内方法来回答药理学和 毒理学重点是代谢，药物设计，药物动力学，药代动力学和信号传导。 T-Spat计划的理由是，这种类型的培训将为学生提供更广泛的 关于药理学和毒理学的观点，可以更好地做好准备，以进行安全，道德和严格 作为药物科学多学科研究团队的领导者的研究。我们将整合t- 在我们在小石城的研究生培训网站上已经活跃的博士培训计划包括 医学，药房和公共卫生学院的教师/科学家，UAMS，阿肯色州 儿童医院校园，以及食品和药物管理局资助的国家毒理中心 研究。 T-ppat的独特重点是训练体内系统药物和毒理学 方法和概念。 T-SPAT的目的是提供体内药理学和毒理学培训 这补充了学生在家庭计划中接受的细胞和分子训练。培训 计划包括药理学，毒理学，生理学，药代动力学，代谢， 生物统计学，赠款写作以及负责任的研究以及实验室研究 人类疾病的体内模型。 T-Spat计划还将提供强大的心理，广泛的网络， 以及通过其编程活动为其培训提供的教学和领导机会。