Integrative Research Training Program in Pediatric Cardiopulmonary Disease

项目总结 这家全国儿童医院(NCH)/俄亥俄州立大学(OSU)T32机构的目标 博士后计划是提供跨学科的，最先进的儿科心脏和心脏研究培训 肺部疾病。婴儿和儿童的心肺疾病是最严重的类型之一 从先天性畸形和单基因疾病到后天获得性疾病的儿科疾病 传染病/炎症性疾病。我们的计划提供了一种独特的集成方法来准备 受训人员将成为科学家和内科科学家，他们将在基础、翻译和临床方面 通过合作、协作的团队科学研究发现。这种整体性的基本原理 方法，从分子发现到使用细胞和动物的翻译方法 模型到人类临床试验，是这些协同方法将更快地影响患者护理和 儿童心肺疾病的治疗。我们将提供一个学术环境， 在一家领先的儿科研究机构接受研究培训，该研究所隶属于一家国际 公认的儿童医院和大学。动态的“双向”研究跟踪将允许临床 内科科学家需要机械地研究的问题和基于发现的新发现 基础研究实验室的基础疾病机制将有效地转化为临床。这 申请寻求在资助期内每年支持4000名学员。研究员将从以下人员中挑选出来 对儿科心肺研究有浓厚兴趣的MD、DO、MD/PHD或博士生 致力于以疾病为导向的调查事业。项目总监在以下方面拥有良好的记录 基础、翻译和临床心肺研究和指导，并将作为培训 项目负责人。培训计划包括实验室和临床研究培训，并辅之以 课程、研讨会、会议以及与行业关系和非传统职业的接触 小路。每个学员将在导师的指导下进行独立研究，根据 个性化的辅导计划。27位导师涵盖的研究领域，包括6 培训中的导师，由他们在NCH的阿比盖尔·韦克斯纳研究所的附属机构代表 以及俄亥俄州立大学。一项积极的、代表性不足的少数族裔招聘和留住计划是 被描述为增加受训人员多样性，是该计划的关键方面，与NCH和 俄亥俄州立大学的战略优先事项。全面的学员和导师评估体系，这是一个不可或缺的组成部分 也包括在培训计划中。确定成功的总体指标包括程序性 由内部和外部咨询委员会进行审查，并成功执行每个受训人员的 个人辅导计划。特定于学员的指标包括所需的课程作业、指导团队 评估，以及以出版物、演示文稿和赠款衡量的研究生产率。

PROJECT SUMMARY The objective of this Nationwide Children’s Hospital(NCH)/Ohio State University(OSU) institutional T32 postdoctoral program is to provide interdisciplinary, state-of-the-art research training in pediatric heart and lung diseases. Cardiopulmonary diseases in infants and children are among the most severe type of pediatric illnesses ranging from congenital malformations and monogenic conditions to acquired infectious/inflammatory diseases. Our program provides a unique integrated approach to prepare trainees to become scientists and physician-scientists who will make basic, translational, and clinical research discoveries through cooperative, collaborative team science. The rationale for this holistic approach, which spans from molecular discovery and translational approaches using cell and animal models to human clinical trials, is that these synergistic methods will more rapidly impact patient care and therapies for children with cardiopulmonary diseases. We will provide an academic environment that cultivates research training at a leading pediatric research institute affiliated with an internationally recognized children’s hospital and university. Dynamic ‘bidirectional’ research tracks will allow for clinical problems to be mechanistically studied by physician-scientists and new, discovery-based findings of fundamental disease mechanisms in basic research labs to be effectively translated to the clinic. This application seeks to support 4 trainees each year over the funding period. Fellows will be selected from MD, DO, MD/PhD, or PhD trainees who hold strong interests in pediatric cardiopulmonary research and are committed to careers in disease-oriented investigation. The Program Directors have strong records in basic, translational, and clinical cardiopulmonary research and mentoring, and will serve as the training program leaders. The training plan consists of laboratory and clinical research training supplemented by courses, seminars, conferences, and exposure to industry relationships and non-traditional career pathways. Each trainee will perform independent research under the direction of a mentor according to an individualized mentoring program. The research areas encompassed by the 27 mentors, including 6 Mentors-in-Training, are represented by their affiliations at the Abigail Wexner Research Institute at NCH and The Ohio State University. An aggressive underrepresented minority recruitment and retention plan is described to increase trainee diversity, and is a critical aspect of this program, which aligns with NCH and OSU strategic priorities. A comprehensive trainee and mentor evaluation system, an integral component of the training program, is also included. Overall metrics to determine success include programmatic review by internal and external advisory committees and the successful execution of each trainee’s individual mentoring program. Trainee-specific metrics include required coursework, mentoring team evaluations, and research productivity as measured by publications, presentations, and grants.