Integrative Research Training Program in Pediatric Cardiopulmonary Disease

项目摘要 这个全国儿童医院（NCH）/俄亥俄州州立大学（OSU）机构T32的目标 博士后计划是提供跨学科，国家的最先进的研究培训，在儿科心脏和 肺部疾病婴儿和儿童的心脏病是最严重的类型 从先天性畸形和单基因疾病到后天性 传染性/炎症性疾病。我们的计划提供了一个独特的综合方法来准备 学员成为科学家和医生，科学家谁将使基本的，翻译，和临床 通过合作、协作的团队科学进行研究发现。这个整体的基本原理 方法，其跨越了使用细胞和动物的分子发现和翻译方法， 这些协同方法将更快地影响患者护理， 治疗儿童心肺疾病。我们将提供一个学术环境， 培养研究培训在一个领先的儿科研究所附属于国际 儿童医院和大学。动态的“双向”研究轨道将允许临床 物理学家科学家和新的，基于发现的发现， 基础研究实验室中的基本疾病机制将有效地转化为临床。这 申请旨在资助期间每年资助4名学员。研究员将从以下人员中选出： MD、DO、MD/PhD或PhD学员，对儿科心肺研究有浓厚兴趣， 致力于疾病导向的研究项目主管在以下方面有着良好的记录： 基础，转化和临床心肺研究和指导，并将作为培训 节目主持人。培训计划包括实验室和临床研究培训， 课程，研讨会，会议，并接触行业关系和非传统职业 途径。每个受训者将根据一个指导者的指导下进行独立的研究， 个性化的指导计划。27位导师所涵盖的研究领域，包括6 培训导师，由他们在NCH阿比盖尔韦克斯纳研究所的附属机构代表 和俄亥俄州州立大学。一项积极的少数族裔招聘和保留计划是 描述为增加学员的多样性，是该计划的一个关键方面，与NCH和 OSU的战略重点。一个全面的学员和导师评估系统， 培训计划也包括在内。确定成功的总体指标包括： 内部和外部咨询委员会的审查以及每个受训者的成功执行 个人辅导计划。特定于受训者的指标包括所需的课程作业、指导团队 评估和研究生产力，通过出版物，演示文稿和赠款来衡量。

PROJECT SUMMARY The objective of this Nationwide Children’s Hospital(NCH)/Ohio State University(OSU) institutional T32 postdoctoral program is to provide interdisciplinary, state-of-the-art research training in pediatric heart and lung diseases. Cardiopulmonary diseases in infants and children are among the most severe type of pediatric illnesses ranging from congenital malformations and monogenic conditions to acquired infectious/inflammatory diseases. Our program provides a unique integrated approach to prepare trainees to become scientists and physician-scientists who will make basic, translational, and clinical research discoveries through cooperative, collaborative team science. The rationale for this holistic approach, which spans from molecular discovery and translational approaches using cell and animal models to human clinical trials, is that these synergistic methods will more rapidly impact patient care and therapies for children with cardiopulmonary diseases. We will provide an academic environment that cultivates research training at a leading pediatric research institute affiliated with an internationally recognized children’s hospital and university. Dynamic ‘bidirectional’ research tracks will allow for clinical problems to be mechanistically studied by physician-scientists and new, discovery-based findings of fundamental disease mechanisms in basic research labs to be effectively translated to the clinic. This application seeks to support 4 trainees each year over the funding period. Fellows will be selected from MD, DO, MD/PhD, or PhD trainees who hold strong interests in pediatric cardiopulmonary research and are committed to careers in disease-oriented investigation. The Program Directors have strong records in basic, translational, and clinical cardiopulmonary research and mentoring, and will serve as the training program leaders. The training plan consists of laboratory and clinical research training supplemented by courses, seminars, conferences, and exposure to industry relationships and non-traditional career pathways. Each trainee will perform independent research under the direction of a mentor according to an individualized mentoring program. The research areas encompassed by the 27 mentors, including 6 Mentors-in-Training, are represented by their affiliations at the Abigail Wexner Research Institute at NCH and The Ohio State University. An aggressive underrepresented minority recruitment and retention plan is described to increase trainee diversity, and is a critical aspect of this program, which aligns with NCH and OSU strategic priorities. A comprehensive trainee and mentor evaluation system, an integral component of the training program, is also included. Overall metrics to determine success include programmatic review by internal and external advisory committees and the successful execution of each trainee’s individual mentoring program. Trainee-specific metrics include required coursework, mentoring team evaluations, and research productivity as measured by publications, presentations, and grants.