UNC Research Training Program in Respiratory Diseases and Critical Care

项目总结/摘要 这一新的T32项目的提案名为“呼吸系统疾病研究培训项目， 北卡罗来纳大学教堂山分校的“重症监护”支持6名博士后医学博士， 医学博士/博士或博士学位的研究培训在肺部疾病，强调联合培训计划， 医学和儿科实习生。该计划提供基础，翻译和临床多学科培训 内科和儿科的肺部和重症监护部门的研究，以及我们的 三个研究中心致力于了解肺部健康和疾病。我们的课程提供培训 48名培训师（38名导师，8名初级导师和2名共同导师），来自7个临床（2）和基础科学（5） 在医学院的部门。M.D.受训人员将在3-5年进入临床和研究培训， 旨在为他们提供在学术肺医学领导职业所需的技能。博士 学员通常会在博士后研究的第二年进入，他们将很好地融入社会 他们的项目的基础、转化和临床方面。每个受训者都会有一个学术监督 委员会包括来自不同学科的导师，他们将促进他们的科学成长和职业生涯 发展，包括赠款写作和领导技能。每个学员都将受到DEI文化的欢迎， 参加研讨会，并将融入这种文化。肺部研究的每个领域都是多学科的， 性质，并强调对每一个基础，翻译，临床和影响的影响更广泛的知识 实习生的问题研究领域包括囊性纤维化，原发性纤毛运动障碍，特发性支气管扩张， 健康和疾病中的气道上皮细胞和分子生物学， COPD，呼吸道炎症控制，ARDS期间的炎症和先天免疫反应，以及细菌 和病毒感染，临床试验，比较有效性研究，定性叙述数据分析，以及 重症监护、气道和肺泡的基础和翻译蛋白质组学、气道 健康和疾病中的微生物组，对物理，化学和微生物环境损伤的反应 药物，以及哮喘的临床和基础科学研究。新颖的节目，融合了多学科 性质包括ARDS和重症监护研究，CF研究计划，和燃烧引起的 军队中的支气管炎，每一个都需要广泛的专业知识之间的跨学科互动 来实现他们的目标临床研究将与使用翻译的基本观察结果相结合 生理、生物化学、分子和遗传技术以及组学方法，并将提供培训 在最先进的组学和其他基础技术，生物信息学，数据库设计，使用和分析， 统计解释重点是儿童和成人人群肺部疾病的潜在机制 和开发新的治疗策略。我们的计划为学员提供了发展的机会 作为科学家，成为独立的调查人员和国家社会的领导者。

Project Summary/Abstract This proposal for a new T32 Program titled “UNC Research Training Program in Respiratory Diseases and Critical Care” at The University of North Carolina-Chapel Hill supports 6 postdoctoral trainees with M.D., M.D./Ph.D. or Ph.D. degrees for research training in lung disease, emphasizing a joint training program for Medicine and Pediatric trainees. The Program provides multidisciplinary training in basic, translation and clinical research within the pulmonary and critical care divisions of the Departments of Medicine and Pediatrics and our three Research Centers devoted to understanding lung health and disease. Our Program offers a Training Faculty of 48 trainers (38 mentors, 8 junior mentors and 2 co-mentors) from 7 clinical (2) and basic science (5) departments in the School of Medicine. M.D. trainees will enter at years 3-5 in their clinical and research training, designed to provide them with skills required for a leadership career in academic pulmonary medicine. Ph.D. trainees will typically enter in the second year of their post-doctoral fellowship, and they will be well integrated into the basic, translational and clinical aspects of their project. Each trainee will have a scholarly oversight committee that includes mentors from varying disciplines who will facilitate their scientific growth and career development, including grant writing and leadership skills. Each trainee will be welcomed into a DEI culture, will take workshops, and will become embedded in this culture. Each area of lung research is multidisciplinary in nature and emphasizes a broader knowledge of the basic, translational, clinical and impact implications for each trainee's question. Areas of research include cystic fibrosis, primary ciliary dyskinesia, idiopathic bronchiectasis, cell and molecular biology of airway epithelia in health and disease, leukocyte kinetics and clinical research in COPD, control of airway inflammation, inflammatory and innate immune responses during ARDS and bacterial and viral infections, clinical trials, comparative effectiveness research, analyses of qualitative narrative data, and large cohort studies in critical care, basic and translational proteomics of airways and alveoli, the airway microbiome in health and disease, the responses to injury by physical, chemical, and microbial environmental agents, and clinical and basic science studies in asthma. Novel programs that exemplify the multi-disciplinary nature include ARDS and Critical Care Research, the CF Research Program, and Combustion-induced Bronchitis in the Military, each of which require cross-disciplinary interactions amongst a wide range of expertise to accomplish their goals. Clinical studies will be integrated with basic observations using translational physiologic, biochemical, molecular and genetic technologies, and -omics approaches and will provide training in state-of-the-art –omics and other basic technologies, bioinformatics, database design, use and analyses, and statistical interpretation. Emphasis is on mechanisms underlying lung diseases in pediatric and adult populations and development of novel therapeutic strategies. Our Program provides an opportunity for trainees to develop as scientists and become independent investigators and leaders within the national community.