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Replacing an Animal Resource Facility Cage Washer.

更换动物资源设施笼清洗机。

基本信息

批准号：
7249668
负责人：
Kristen Drescher
金额：
$ 63.82万
依托单位：
CREIGHTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-05-15 至 2009-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Creighton University is an independent, comprehensive Jesuit university located in Omaha, Nebraska. The mission of the Creighton University and its School of Medicine (CUSOM) is to develop and promote understanding of human health and the causes, treatments, and prevention of disease. To this end, Creighton University has been engaged in a major extension of its basic research capacity by expanding and renovating existing buildings and improving five core facilities. Creighton University, and this research faculty, are aware that state-of-the-art animal resource facilities are essential for the continued success of any modern research oriented institution. Creighton University has over the last few years invested $800,000 to expand and improve the mouse carrying capacity by changing our cage system to modern Thoren racks and investing in safety cabinets. We have also modernized our receiving area into a barrier facility for rapid and safe import of new mouse lines. These improvements in the Creighton University animal facility have let to AAALAC certification as of 2005. For this G20 grant we propose to replace the outdated cage washer of our 17,000 square-foot Animal Resource Facility. Specifically, we seek with this proposal financial support to renovate an area for housing of the new cage washer that will be purchased through Creighton University. This proposed renovation of the research areas of the Animal Resource Facility is an integrated part of Creighton's ongoing multi-phased construction, remodeling, and expansion of the Science Complex. The long-term objective for the proposed Animal Resource Facility renovation is to enhance our current research productivity and to provide the animal resources needed for current and future cutting-edge, NIH funded biomedical research. The specific aim of the project is to replace the existing outdated cage washer with a state-of-the-art system. Creighton University will purchase the cage washer and the autoclave. We hope to obtain through this application the support to renovate the existing space in the animal facility to house and operate effectively this new cage washer to generate a nucleus for an already planned barrier facility to house the many transgenic mouse lines already at Creighton University and the additional ones we will soon have.

描述（由申请人提供）：Creighton University是一所独立的综合性耶稣会大学，位于内布拉斯加州奥马哈。克赖顿大学及其医学院的使命是发展和促进对人类健康和疾病的原因，治疗和预防的理解。为此，克赖顿大学一直在通过扩大和改造现有建筑，改善五个核心设施，其基础研究能力的重大扩展。Creighton University和这个研究学院都知道，最先进的动物资源设施对于任何现代研究型机构的持续成功至关重要。在过去的几年里，克雷顿大学已经投资了80万美元，通过将我们的笼子系统改为现代的托伦架和投资安全柜来扩大和提高老鼠的承载能力。我们还将我们的接收区现代化，使其成为一个屏障设施，以便快速安全地进口新的小鼠品系。Creighton大学动物设施的这些改进使其在2005年获得了AAALAC认证。对于这项G20赠款，我们建议更换我们17，000平方英尺的动物资源设施的过时的笼子垫圈。具体来说，我们寻求与此建议的财政支持，以翻新一个地区的住房新笼洗衣机，将通过克雷顿大学购买。动物资源设施研究领域的这一拟议改造是克雷顿正在进行的多阶段建设，改造和科学综合体扩建的一个组成部分。拟议的动物资源设施改造的长期目标是提高我们目前的研究生产力，并为当前和未来的尖端，NIH资助的生物医学研究提供所需的动物资源。该项目的具体目标是用最先进的系统取代现有过时的笼式洗涤机。克雷顿大学将购买笼式洗衣机和高压灭菌器。我们希望通过这项申请获得支持，以改造动物设施中的现有空间，以容纳和有效地操作这种新的笼式洗衣机，为已经计划的屏障设施提供核心，以容纳Creighton大学已经拥有的许多转基因小鼠品系以及我们即将拥有的其他品系。

项目成果

期刊论文数量（50）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity.

DOI：
10.1016/j.neuropharm.2015.02.013
发表时间：
2015-06
期刊：
Neuropharmacology
影响因子：
4.7
作者：
Gupta SC;Yadav R;Pavuluri R;Morley BJ;Stairs DJ;Dravid SM
通讯作者：
Dravid SM

Effect of D-cycloserine in conjunction with fear extinction training on extracellular signal-regulated kinase activation in the medial prefrontal cortex and amygdala in rat.

DOI：
10.1111/ejn.12197
发表时间：
2013-06
期刊：
The European journal of neuroscience
影响因子：
0
作者：
Gupta SC;Hillman BG;Prakash A;Ugale RR;Stairs DJ;Dravid SM
通讯作者：
Dravid SM

Region-specific Expression of NMDA Receptor GluN2C Subunit in Parvalbumin-Positive Neurons and Astrocytes: Analysis of GluN2C Expression using a Novel Reporter Model.

DOI：
10.1016/j.neuroscience.2018.03.011
发表时间：
2018-06-01
期刊：
Neuroscience
影响因子：
3.3
作者：
Ravikrishnan A;Gandhi PJ;Shelkar GP;Liu J;Pavuluri R;Dravid SM
通讯作者：
Dravid SM

Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory.

DOI：
10.1016/j.nlm.2011.01.008
发表时间：
2011-05
期刊：
NEUROBIOLOGY OF LEARNING AND MEMORY
影响因子：
2.7
作者：
Hillman, Brandon G.;Gupta, Subhash C.;Stairs, Dustin J.;Buonanno, Andres;Dravid, Shashank M.
通讯作者：
Dravid, Shashank M.

In vivo ketogenic diet treatment attenuates pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices from epileptic Kv 1.1α knockout mice.