Leveraging mHealth to Increase Health Equity among Black Individuals with Opioid Use Disorder and Commonly Occurring Mental Health Disorders

项目摘要 该研究科学家发展奖(K01)的首要目标是为Hannah Szlyk博士提供 培训和研究活动需要成为独立的研究人员，开发、测试和 实施尖端数字治疗干预措施，促进康复过程中的健康公平 阿片类药物使用障碍(OUD)加上常见的精神障碍(COMD)。此应用程序概述了一个 综合培训和研究计划，将为Szlyk博士提供实现其职业生涯所需的技能 进球。在临床试验专家的指导下，健康公平，实施科学，以用户为中心 Szlyk博士的培训将集中在以下关键领域：(1)临床试验 方法论(Esther Lu博士；(2)实现科学和以用户为中心的设计(Patricia Cavazos-Rehg博士 和艾米丽·C·威廉姆斯)；以及(3)成瘾和心理健康方面的健康公平(达雷尔·哈德森博士)。培训 在这三个领域将通过教学和应用活动、参与国家 会议和研究所，以及辅导会议。Szlyk博士将应用在培训中学到的技能 开展研究项目，以适当适应和测试针对黑人的移动健康干预措施 美国人有OUD加COMD。年，美国黑人与阿片类药物相关的死亡率继续上升 美国。这些死亡通常集中在中等大城市，如圣路易斯， 密苏里州，这项研究的背景。然而，很少有干预措施被开发来满足Black的独特需求 客户；没有人解决他们服用过量药物的风险增加的问题，这往往会加剧COMD，这会降低可能性 为了复苏的成功。此外，黑人个体在接受OUD治疗时也会遇到重大障碍，比如 由于结构性种族主义，对穆德(Moud)的药物治疗。为了解决这一差距，K01研究项目将 整合公共卫生关键竞赛实践、实施科学和以用户为中心的设计战略，以 适当地为美国黑人调整MHealth干预措施，使用OUD和COMD。中环 假设是，适应移动健康干预将提高黑人的参与度和可用性 参与者，提高对Moud的坚守，COMD的影响降低。这项研究将解决关键问题 治疗方面的差距：1)为患有OUD和COMD的黑人患者调整mHealth干预措施；2) 确定在服务的利益相关者中实施移动健康干预的障碍和促进者 使用OUD和COMD的黑人；3)检查适应的mHealth干预的初步效果。 这些数据将为未来R01应用程序设计更大的RCT提供信息。Szlyk博士的训练和 建议的研究将在华盛顿大学杰出的智力环境中进行 这将为她提供大量资源来实现她的目标。

Project Summary The overarching goal of this Research Scientist Development Award (K01) is to provide Dr. Hannah Szlyk with the training and research activities needed to become an independent researcher who develops, tests, and implements cutting-edge digital therapeutic interventions that can promote health equity in recovery from opioid use disorder (OUD) plus commonly occurring mental disorders (COMD). This application outlines an integrated training and research plan that will provide Dr. Szlyk with the skills needed to achieve her career goal. Under the mentorship of experts in clinical trials, health equity, implementation science, user-centered design, and OUD research, Dr. Szlyk’s training will focus on the following key areas: (1) clinical trial methodology (Dr. Esther Lu; (2) implementation science and user-centered design (Drs. Patricia Cavazos-Rehg and Emily C. Williams); and (3) health equity in addictions and mental health (Dr. Darrell Hudson). Training in these three areas will be achieved through didactic and applied activities, participation in national conferences and institutes, and mentoring meetings. Dr. Szlyk will apply the skills acquired during the training activities to conduct a research project to appropriately adapt and test an mHealth intervention for Black Americans with OUD plus COMD. Rates of opioid-related deaths continue to rise among Black Americans in the United States. These deaths are often concentrated in medium-sized metropolitan cities, like St. Louis, Missouri, where this research is set. Yet, few interventions are developed to fit the unique needs of Black clients; none address their heightened overdose risk often compounded by COMD which decreases likelihood for recovery success. Also, Black individuals experience significant barriers to life saving OUD treatments, like medication for OUD (MOUD), because of structural racism. To address this gap, the K01 research project will integrate public health critical race praxis, implementation science, and user-centered design strategies to appropriately adapt an mHealth intervention for Black Americans with OUD plus COMD. The central hypothesis is that adaptations to the mHealth intervention will improve engagement and usability among Black participants, improve adherence to MOUD, and impact decreases in COMD. This research will address key gaps in treatment by 1) adapting an mHealth intervention for Black individuals with OUD plus COMD; 2) identifying barriers and facilitators to implementing an mHealth intervention among stakeholders who serve Blacks with OUD plus COMD; 3) examining the preliminary efficacy of an adapted mHealth intervention. These data will inform the design of a larger RCT for a future R01 application. Dr. Szlyk’s training and proposed research will be carried out in the outstanding intellectual environment of Washington University School of Medicine, which will provide her with a multitude of resources to meet her goals.