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An Intervention to Reduce Cancer Associated Thrombosis Through Improved Prophylaxis

通过改进预防来减少癌症相关血栓形成的干预措施

基本信息

批准号：
10723791
负责人：
Jordan Schaefer
金额：
$ 17.14万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-15 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10723791
关键词：
Academic Medical Centers Active Learning Address Agreement American Society of Clinical Oncology American Society of Hematology Anticoagulants Anticoagulation Assessment tool Award Awareness Caring Cause of Death Cessation of life Clinic Clinical Investigator Clinical Trials Coagulation Process Collaborations Communities Community Practice Complex Data Data Analyses Dedications Dose Educational workshop Eligibility Determination Environment Foundations Goals Guidelines Health Policy Hematologist Hemorrhage Hemostatic function Incidence Institution International Intervention Interview Jordan K-Series Research Career Programs Life Malignant Neoplasms Maps Mentors Mentorship Michigan Multicenter Studies National Comprehensive Cancer Network Oncologist Oncology Oral Outcome Outpatients Participant Patient Care Patients Patterns of Care Pharmacists Physicians Population Prophylactic treatment Qualitative Methods Qualitative Research Quality of Care Recommendation Research Research Methodology Research Personnel Research Project Grants Resource-limited setting Resources Risk Risk Assessment Risk Reduction Sampling Self Efficacy Site Societies Structure Testing Theoretical Domains framework Thrombosis Time Training Training Activity Universities cancer risk cancer therapy chemotherapy clinical efficacy clinical practice community setting cost efficacy evaluation evidence base experience high risk implementation evaluation implementation intervention implementation outcomes implementation process implementation science implementation strategy improved innovation interest meetings member multi-component intervention multidisciplinary novel patient population pharmacologic pilot test preventive intervention skill acquisition skills success thrombotic uptake venous thromboembolism

项目摘要

Candidate: Jordan Schaefer, MD is a hematologist and early clinical investigator specializing in antithrombotic therapies, with particular interests in implementation science and cancer associated thrombosis (CAT). Training Aims: This K01 career development award will facilitate Dr. Schaefer receiving training in qualitative research methods and analysis. Furthermore, he will develop skills in implementation science, including implementation mapping, and conducting a multicenter pilot implementation intervention. He will acquire these skills through focused mentorship meetings, formal coursework, workshops and seminars, and experiential learning. Long term, he will use this training to optimize and implement multicomponent interventions to promote best antithrombotic therapies. Research Context: CAT is a leading cause of death among patients with cancer. Studies have shown a net benefit to anticoagulant thromboprophylaxis for high-risk patients with cancer receiving systemic cancer therapy. Guidelines have broadly endorsed offering apixaban or rivaroxaban for this patient population, but uptake has been extremely low. An academic medical center was able to increase prophylaxis rates to over 90% of eligible patients. However, this intervention is not generalizable to community settings where most patients receive their care. The short-term goal of this proposal is to identify strategies to improve rates of CAT prophylaxis rates in low resource, community settings with a long-term goal of broadly disseminating this intervention to reduce the incidence of CAT. Specific Aims: AIM 1–To identify determinants of CAT prophylaxis in community-based oncology care settings to develop a strategy for improving CAT prophylaxis. AIM 2–To develop an implementation plan to improve the uptake of pharmacologic prophylaxis for CAT using implementation mapping. AIM 3–To pilot an implementation intervention at community-based oncology practices. Research Plan: To accomplish these aims, Dr. Schaefer will perform semi-structured interviews based on the Theoretical Domains Framework at several oncology practices. He will meet regularly with diverse stakeholders and use implementation mapping to establish a multicomponent implementation plan. Finally, he will conduct a pilot test of the intervention and assess implementation outcomes six oncology clinics. Research Environment: Dr. Schaefer is supported by a dedicated, multidisciplinary team of accomplished mentors and advisors with whom he has previously collaborated. The project will be supported by the Michigan Oncology Quality Consortium, the Michigan Anticoagulation Quality Improvement Initiative, and make use of several resources available at the University of Michigan, including the Institute for Healthcare Policy and Innovation. Summary: Completing this project will establish the foundation for a larger, multicenter study to establish the clinical efficacy and sustainability of this intervention. The training from this award will prepare Dr. Schaefer to submit a successful R01 application and achieve research independence using implementation science principles to address complex anticoagulation problems.

候选人：Jordan Schaefer，医学博士，血液学家和早期临床研究者，专门研究抗血栓