Melanoma Mutation Profiling For Personalised Treatment

黑色素瘤突变分析用于个性化治疗

• 批准号: nhmrc : 1046711
• 负责人: Dr Elin Gray
• 金额: $ 38.09万
• 依托单位: Edith Cowan University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/melanoma-mutation-profiling-personalised-treatment/111866
• 关键词: Melanoma; Mutation; Profiling; Personalised; Treatment

Melanoma is an aggressive skin cancer, and the leading cause of skin cancer related deaths. Disease spread is difficult to detect and extremely difficult to cure. This bleak clinical outcome is changing with the development of personalised therapies which include small molecule inhibitors to treat metastatic melanoma. Here we seek to identify the spectrum of mutations in patient tumours and circulating tumour cells for advanced personalised treatment.

黑色素瘤是一种侵袭性皮肤癌，是皮肤癌相关死亡的主要原因。疾病的传播很难发现，也很难治愈。随着包括小分子抑制剂在内的个性化治疗的发展，这种暗淡的临床结果正在改变，以治疗转移性黑色素瘤。在这里，我们试图确定患者肿瘤和循环肿瘤细胞中的突变谱，以进行先进的个性化治疗。