Hematopoiesis training grant

描述（由申请人提供）：自1978年以来，宾夕法尼亚大学的血液学/肿瘤学部门一直正式参与组织学术科学家的培训。在此期间，培训计划的目标是帮助对血液学相关研究感兴趣的优秀候选人为实验室和/或临床研究的学术生涯做好准备。这项培训计划的成功记录令人钦佩。在完成课程的64名学员中，有41人（64%）目前在美国约21个机构担任全职职务，所有这41人都从事实验室（-33%）或临床（-66%）研究。此外，我们的前受训人员中约有一半获得了校外研究经费，1998财政年度的直接费用超过700万美元。基于这种卓越和成功的传统，我们现在寻求在干细胞生物学和造血领域建立一个额外的，更高度集中的培训计划。设立这一专门培训方案的理由是基于若干因素。首先，在血液学/肿瘤学部门和更广泛的大学社区中，对造血和干细胞生物学感兴趣的实验室有了显着的扩展。在实验室和教师谁共享造血作为一个主要焦点的增加创造了一个令人兴奋的环境，吸引了越来越多的博士后和博士前学生到大学。因此，建立这个培训计划的第二个原因是潜在学员的需求。最后，这些实验室正在进行的工作是高度转化的，与基因治疗和癌症治疗领域有很大的相关性。因此，无论学生选择培训的子区域如何，完成该计划的个人都很可能因为他们成功竞争校外资金的能力以及他们可能对医疗保健的进步做出的潜在贡献而受到欢迎。

DESCRIPTION (provided by applicant): The Hematology/Oncology Division at the University of Pennsylvania has been formally engaged in organizing the training of academic scientists since 1978. Throughout this time, the goal of the training program has been to help outstanding candidates with an interest in hematology related research to prepare themselves for academic careers in laboratory and/or clinical investigation. The record of success of this training program has been admirable. Of the 64 trainees who completed their program, 41 (64%) presently hold full-time appointments at some 21 institutions throughout the United States, and all of these 41 individuals are engaged in either laboratory (-33%) or clinical (-66%) research. Further, approximately half of our former trainees have extramural research funding, with direct costs in Fiscal year '98 exceeding $7 million. Based on this tradition of excellence and success, we now seek to establish an additional, more highly focused training program in the area of stem cell biology and hematopoiesis. The justification for establishing this specialized training program is based on a number of factors. First, there has been a significant expansion of laboratories interested in hematopoiesis and stem cell biology in the Division of Hematology/Oncology and in the wider University community as well. The increase in laboratories and faculty who share hematopoiesis as a primary focus has created an exciting environment which is attracting increasing numbers of post-doctoral and pre-doctoral students to the University. Therefore, the second reason to establish this training program is demand by potential trainees. Finally, the work being carried out in these laboratories is highly translational with great relevance to the field of gene therapy and the treatment of cancer. Therefore, regardless of the sub-area in which students elect to train, it is deemed quite likely that individuals who complete this program will be much in demand as a result of their ability to compete successfully for extramural funding and for the potential contributions they may make to the advancement of medical care.