Biological Imaging Module

生物成像模块

• 批准号: 10724942
• 负责人: Nimesh Bhikhu Patel
• 金额: $ 11.17万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724942
• 关键词: 3-Dimensional; Animals; Biological; Biophysics; Center Core Grants; Computer Assisted; Computer-Assisted Image Analysis; Confocal Microscopy; Cornea; Doctor of Philosophy; Electron Microscopy; Equipment; Equity; Face; Fluorescence Microscopy; Funding; Grant; Histology; Human Resources; Image; Image Analysis; Individual; Light; Microscopy; Molecular; Optical Coherence Tomography; Research; Research Personnel; Resolution; Resources; Retina; Scanning Electron Microscopy; Services; Techniques; Training; Transmission Electron Microscopy; Universities; Vision research; imaging Segmentation; imaging facilities; in vivo; in vivo imaging; innovation; interest; light microscopy; live cell imaging; reconstruction; skills; tissue preparation; tomography; two photon microscopy

The Biological Imaging Module of the Center Core Grant for Vision Research provides state of the art imaging facilities to support and advance innovative research by investigators at the University of Houston. The Module provides a wide range of up-to-date imaging equipment for use by Core investigators and their collaborators, and newly hired investigators, who have interests in structural, cellular, and molecular aspects of vision research. Specifically, the Module provides facilities for tissue preparation, standard light microscopy, confocal microscopy, deconvolution fluorescence microscopy, two-photon microscopy, light sheet microscopy, live cell imaging, transmission electron microscopy (TEM), scanning electron microscopy SEM and serial block-face (SBF-SEM) imaging, computer-assisted image segmentation and 3D reconstruction, and Retinal and Corneal Tomography and Spectral Domain – Optical Coherence Tomography (SD-OCT) for in vivo imaging of small animals. The Module is staffed by two a highly skilled personnel: an expert microscopist/histology technologist and an accomplished biophysical microscopist with expertise in many aspects of advanced light microscopy. These individuals coordinate use, assist with histology/microscopy and provide a full range of training that spans basic to advanced techniques. The Biological Imaging Module is supervised by Nimesh B. Patel, OD, PhD who has two active R01 grants funded by NEI, substantial expertise in light and electron microscopy, and in vivo OCT imaging and computer-assisted image analyses.

视觉研究中心核心拨款的生物成像模块提供了以下状态： 艺术成像设施，以支持和推进研究人员的创新研究 休斯顿大学。该模块提供了广泛的最新成像设备， 核心研究者及其合作者以及新聘用的研究者使用， 对视觉研究的结构、细胞和分子方面感兴趣。具体来说，模块 提供组织制备、标准光学显微镜、共聚焦显微镜 去卷积荧光显微术，双光子显微术，光片显微术，活细胞 成像，透射电子显微镜（TEM），扫描电子显微镜SEM和连续 块面（SBF-SEM）成像，计算机辅助图像分割和3D重建， 视网膜和角膜断层扫描和光谱域-光学相干断层扫描 （SD-OCT）用于小动物的体内成像。该模块由两名高技能的 人员：一名显微镜专家/组织学技术专家和一名熟练的生物物理学家 在先进光学显微镜的许多方面具有专业知识的显微镜学家。这些人 协调使用，协助组织学/显微镜检查，并提供涵盖 从基础到高级技术。生物成像模块由Nimesh B监督。帕特尔， 拥有NEI资助的两项R 01赠款，在光和电子方面具有丰富的专业知识 显微镜和体内OCT成像和计算机辅助图像分析。