Delineating the kidney brain axis in children with severe malaria (KID-BRAIN)

描绘严重疟疾儿童的肾脑轴（KID-BRAIN）

• 批准号: 10734142
• 负责人: Anthony Batte
• 金额: $ 9.65万
• 依托单位: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-20 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10734142
• 关键词: Acute; Acute Renal Failure with Renal Papillary Necrosis; Address; African; Award; Biological Markers; Brain; Brain Edema; Brain Injuries; Brain imaging; Cell Cycle Arrest; Cerebral Edema; Child; Childhood; Childhood Injury; Chronic Kidney Failure; Clinical; Coma; Communities; Creatinine; Data; Data Analyses; Detection; Development; Development Plans; Diagnosis; Endothelium; Epidemiology; Evaluation; Fever; Filtration; Fogarty International Center; Funding; Future; Goals; Growth and Development function; Health Sciences; Hospitalization; Image Analysis; Injury; Injury to Kidney; Intervention; Intervention Studies; Kidney; Kidney Diseases; Knowledge; Lead; Learning; Link; Longevity; Longitudinal Studies; Magnetic Resonance Imaging; Malaria; Malnutrition; Mentors; National Institute of Neurological Disorders and Stroke; Neuroglia; Neurological outcome; Observational Study; Osmolar Concentration; Outcome; Pathogenesis; Pathway interactions; Patients; Phenotype; Physicians; Plasma; Population; Positioning Attribute; Problem behavior; Publishing; Recovery; Research; Research Personnel; Research Training; Risk Factors; Sampling; Scientist; Serum; Sickle Cell Anemia; Site; Stress; Stroke; Structure; Teacher Professional Development; Testing; Time; Training; Translating; United States National Institutes of Health; Universities; Urea; Work; biosignature; blood-brain barrier disruption; brain health; career; career development; cell injury; clinical diagnosis; college; disability; early childhood; education planning; evidence base; follow-up; immune activation; improved; lecturer; mortality; neurobehavioral; point of care testing; predictive marker; prevent; prospective; skills; tool

Project summary/ abstract The overall goal of this career award is to build Dr Batte into an independently funded physician scientist improving survival of children with acute kidney injury (AKI) and identify interventions that will enable children to thrive. Dr Batte will delineate mechanisms of kidney-related brain injury in children with severe malaria. Dr Batte is a Lecturer and a Pediatric nephrologist at Makerere University college of health sciences. From his past research work, he has established evidence-based approaches to AKI diagnosis and phenotypic characterization. He has explored the utility of point-of-care tests in evaluating AKI, and has mechanistically compared severe malaria AKI and non-malaria febrile illnesses related AKI demonstrating differences in endothelial activation and immune activation. He has also evaluated brain injury and neurological outcomes of children with AKI following acute malnutrition and sickle cell anemia. He has published an invited review highlighting challenges in the diagnosis and management of AKI in children and outlined priorities for future research, which included detailed neuro-developmental assessments following AKI in children with severe malaria. Dr Batte will use the 75% protected time for the next 5 years working with his mentors to understand how acute changes in brain-kidney crosstalk translate to long-term injury and to identify modifiable pathways amenable to intervention to promote adaptive kidney and brain recovery following severe malaria. Dr Batte has developed an educational plan that builds on his past training and addresses research training gaps, that once filled will provide the basis to propel him into an independent research career. This K43 will be structured around specialized training in neurobehavioral evaluation along with biomarker testing and interpretation. It will help Dr Batte to achieve his objectives which are to; (1) determine the extent that AKI phenotypes are associated with biosignatures of brain injury and recovery (2) establish the extent that AKI and AKI phenotypes are associated with cerebral edema (3) define the association between neurobehavioral outcomes, brain injury biomarkers and AKI phenotypes. Dr Batte will attain a number of skill-sets in kidney and brain biomarker testing and interpretation, skills in brain imaging interpretation, data analysis and conduct of longitudinal studies, and neurobehavioral evaluation of children. It is expected that at completion of this award, with the developed expertise and data generated, he will elucidate modifiable pathways of kidney-brain cross talk in severe malaria, setting the stage for an R01 application and a platform for future intervention studies to prevent injury and promote brain and kidney recovery following severe malaria.

项目概要/摘要 该职业奖的总体目标是将Batte博士培养成一名独立资助的医生科学家 提高急性肾损伤（阿基）儿童的存活率，并确定能够 孩子们茁壮成长。Batte博士将描述严重脑损伤儿童肾相关脑损伤的机制。 疟疾Batte博士是Makerere大学健康学院的讲师和儿科肾病学家 以理工科为重从他过去的研究工作中，他建立了基于证据的阿基诊断方法 和表型表征。他探索了即时检验在评估阿基中的效用， 从机制上比较了严重疟疾阿基和非疟疾发热性疾病相关阿基， 内皮激活和免疫激活的差异。他还评估了脑损伤， 急性营养不良和镰状细胞性贫血后阿基儿童的神经系统结局。他 发表了一篇特邀综述，强调了儿童阿基诊断和管理方面的挑战， 概述了未来研究的优先事项，其中包括详细的神经发育评估， 严重疟疾儿童的阿基。Batte博士将在未来5年内使用75%的受保护时间 与他的导师一起了解脑肾串扰的急性变化如何转化为长期损伤 并确定适合干预的可改变途径，以促进适应性肾脏和大脑 严重疟疾后的康复。巴特博士根据他的过去制定了一项教育计划 培训和解决研究培训差距，一旦填补将提供基础，推动他成为一个 独立的研究生涯。这个K43将围绕神经行为方面的专门培训而构建 评价沿着生物标志物测试和解释。这将有助于巴特博士实现他的目标 其目的是：（1）确定阿基表型与脑损伤生物特征相关的程度 （2）确定阿基和阿基表型与脑水肿相关的程度（3） 定义神经行为结果、脑损伤生物标志物和阿基表型之间的关联。博士 Batte将获得肾脏和大脑生物标志物测试和解释方面的一些技能， 影像学解释、数据分析和纵向研究的进行，以及神经行为评价， 孩子预计在完成这项授予后，随着开发的专门知识和产生的数据， 他将阐明严重疟疾中肾脑相互作用的可改变途径， R 01应用程序和未来干预研究的平台，以防止损伤和促进大脑和 严重疟疾后的肾脏恢复。