Cannabis Use and Proximal Immune Dysregulation (CUPID)

大麻使用和近端免疫失调（CUPID）

基本信息

批准号：
10760742
负责人：
Renessa Williams
金额：
$ 16.41万
依托单位：
UNIVERSITY OF MIAMI CORAL GABLES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-25 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10760742
关键词：
Acceleration Address Adolescent Age Anti-Inflammatory Agents Attenuated Biological Biological Markers Biological Process Black Populations Black race CD4 Lymphocyte Count Cannabis Cell Aging Chicago Chromosomes Chronic stress Cohort Studies Communities Complement Cross-Sectional Studies DNA Structure Data Demographic Survey Development Discrimination Disease Epidemic Exposure to Funding Gays Generations Goals HIV HIV Infections HIV disparities Health Homophobia Housing Immune Immune system Individual Inflammation Inflammatory Infrastructure Investigation Legal Length Lesbian Gay Bisexual Transgender Queer Leukocytes Life Life Cycle Stages Life Expectancy Link Measures Mental Health Mentors Mentorship Modeling Morbidity - disease rate Neighborhoods Neuroimmune Not Hispanic or Latino Occupations Outcome Parents Participant Pathogenesis Pathway interactions Patient Self-Report Persons Pharmacology Plasma Play Population Predisposition Process Property Research Research Activity Research Personnel Risk Role Sampling Severities Social Conditions Stress Stress and Coping Symptoms Therapeutic Training Training Activity United States National Institutes of Health Untranslated RNA Urine Victimization Violence Viral Load result Weather Work age related biobehavior black men career career development cohort comorbidity critical period early life exposure emerging adulthood experience fortification health disparity internalized stigma longitudinal analysis marijuana use men minority stress monocyte mortality physical conditioning preservation racial disparity racial minority racism sexual identity sexual minority group sexual minority men sexual minority stress sleep health social social health determinants social stigma sociodemographics stimulant use telomere therapy development

项目摘要

PROJECT SUMMARY/ABSTRACT Background. Black sexual minority men (SMM) experience profound HIV-related disparities compared to non- Hispanic White men, acquiring age-related diseases with greater symptom severity earlier in the life course and dying from HIV infection at higher rates. Early life exposure to stress is linked to key biological processes, specifically inflammation and shorter leukocyte telomere length, which are associated with HIV-related comorbidities and age-related diseases. It is well documented that young Black SMM experience multilevel sexual minority stress, such as sexual identity concealment, victimization, and community homophobia - products of stigma which further complicate health outcomes. Thus, understanding factors that may attenuate the effects of inflammation in younger ages is a critical period to mitigate HIV-related disparities later in life. Cannabis use is a noteworthy modifiable factor for investigation, given the substantial evidence of its role in anti- inflammatory processes and its rapidly accelerating legal and social acceptance; however, the rigor of prior research examining the influence of cannabis on inflammation and other key biological processes is limited because studies have mostly been cross-sectional, used self-reported measures of cannabis use, and are not generalizable to young Black SMM with HIV. To address these gaps, this K23 proposal – Cannabis Use and Proximal Immune Dysregulation (CUPID) – will fortify my Career Development efforts to (1) understand how biomarkers of cannabis may influence inflammation and leukocyte telomere length and (2) examine the modifying role of multilevel sexual minority stress. This K23 proposal will chart a pathway to achieve my long- term Career Goals of becoming an R01-funded investigator with expertise in multilevel determinants of biobehavioral processes underpinning HIV-related health disparities to guide the development of interventions with Black SMM with HIV. To accomplish my career goals, I will need training (1) to develop a comprehensive understanding of biomarkers of cannabis use, inflammation, and leukocyte telomere length; (2) to advance my understanding of multilevel sexual minority stress assessment in Black SMM; and (3) to develop expertise in analyzing longitudinal data. An accomplished, interdisciplinary Mentorship Team committed to supporting my transition to an independent investigator will provide guidance on the training and research activities. Specific Aims are (1) to determine the relationship between cannabis use and biomarkers of inflammation and leukocyte telomere length; and (2) to evaluate whether individual- interpersonal- community- and societal level sexual minority stress moderate the relationship of cannabis with inflammation and leukocyte telomere length. CUPID will inform the development of an R01 proposal for a more definitive cohort study to further elucidate the bio- behavioral pathways whereby cannabis use, and sexual minority stress are linked to inflammation and leukocyte telomere length in Black SMM with HIV.

项目摘要/摘要背景。黑人性少数族裔男性（SMM）与非 - 非 - 西班牙裔白人，在生命过程中以更大的症状严重程度获得与年龄有关的疾病以较高的速度死于艾滋病毒感染。早期生活承受压力与关键生物过程有关，特别是炎症和较短的白细胞端粒长度，与HIV有关合并症和与年龄有关的疾病。有充分记录的年轻黑人SMM体验多级性少数派压力，例如性认同隐瞒，胜利和社区同性恋 - 污名产物，使健康结果更加复杂。这是了解可能减弱的因素年轻时炎症的影响是减轻与HIV相关的差距的关键时期。鉴于其在反 - 炎症过程及其迅速加速的法律和社会接受；但是，先验的严峻研究研究大麻对注射和其他关键生物过程的影响的研究有限因为研究主要是横截面的，使用了自我报告的大麻使用量度，而不是可推广到年轻的黑色SMM和艾滋病毒。为了解决这些差距，该K23提案 - 大麻使用和近端免疫失调（丘比特） - 将加强我的职业发展努力，以了解如何了解大麻的生物标志物可能影响注射和白细胞端粒长度，（2）检查修改多层次性少数族裔压力的作用。该K23提案将列出实现我长期的途径成为R01资助的调查员的任期职业目标，具有多级决定者的专业知识与HIV相关的健康差异的基础的生物行为过程指导干预措施的发展与艾滋病毒的黑色SMM。为了实现我的职业目标，我将需要培训（1）来发展全面了解大麻使用，感染和白细胞端粒长度的生物标志物；（2）促进我的了解黑人SMM中多级性少数族裔压力评估；（3）发展专业知识分析纵向数据。一个成就卓越的跨学科指导团队致力于支持我的过渡到独立研究者将为培训和研究活动提供指导。具体的目的是（1）确定大麻使用与炎症和白细胞生物标志物之间的关系端粒长度；（2）评估个人与社区和社会层面是否性少数族裔压力适应大麻与炎症和白细胞端粒长度的关系。丘比特将告知R01提案的开发，以进行更明确的队列研究，以进一步阐明生物大麻使用和性少数压力的行为途径与炎症和白细胞有关黑色SMM的端粒长度和艾滋病毒。