Cannabis Use and Proximal Immune Dysregulation (CUPID)

大麻使用和近端免疫失调（CUPID）

• 批准号: 10760742
• 负责人: Renessa Williams
• 金额: $ 16.41万
• 依托单位: UNIVERSITY OF MIAMI CORAL GABLES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-25 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10760742
• 关键词: Acceleration; Address; Adolescent; Age; Anti-Inflammatory Agents; Attenuated; Biological; Biological Markers; Biological Process; Black Populations; Black race; CD4 Lymphocyte Count; Cannabis; Cell Aging; Chicago; Chromosomes; Chronic stress; Cohort Studies; Communities; Complement; Cross-Sectional Studies; DNA Structure; Data; Demographic Survey; Development; Discrimination; Disease; Epidemic; Exposure to; Funding; Gays; Generations; Goals; HIV; HIV Infections; HIV disparities; Health; Homophobia; Housing; Immune; Immune system; Individual; Inflammation; Inflammatory; Infrastructure; Investigation; Legal; Length; Lesbian Gay Bisexual Transgender Queer; Leukocytes; Life; Life Cycle Stages; Life Expectancy; Link; Measures; Mental Health; Mentors; Mentorship; Modeling; Morbidity - disease rate; Neighborhoods; Neuroimmune; Not Hispanic or Latino; Occupations; Outcome; Parents; Participant; Pathogenesis; Pathway interactions; Patient Self-Report; Persons; Pharmacology; Plasma; Play; Population; Predisposition; Process; Property; Research; Research Activity; Research Personnel; Risk; Role; Sampling; Severities; Social Conditions; Stress; Stress and Coping; Symptoms; Therapeutic; Training; Training Activity; United States National Institutes of Health; Untranslated RNA; Urine; Victimization; Violence; Viral Load result; Weather; Work; age related; biobehavior; black men; career; career development; cohort; comorbidity; critical period; early life exposure; emerging adulthood; experience; fortification; health disparity; internalized stigma; longitudinal analysis; marijuana use; men; minority stress; monocyte; mortality; physical conditioning; preservation; racial disparity; racial minority; racism; sexual identity; sexual minority group; sexual minority men; sexual minority stress; sleep health; social; social health determinants; social stigma; sociodemographics; stimulant use; telomere; therapy development

PROJECT SUMMARY/ABSTRACT Background. Black sexual minority men (SMM) experience profound HIV-related disparities compared to non- Hispanic White men, acquiring age-related diseases with greater symptom severity earlier in the life course and dying from HIV infection at higher rates. Early life exposure to stress is linked to key biological processes, specifically inflammation and shorter leukocyte telomere length, which are associated with HIV-related comorbidities and age-related diseases. It is well documented that young Black SMM experience multilevel sexual minority stress, such as sexual identity concealment, victimization, and community homophobia - products of stigma which further complicate health outcomes. Thus, understanding factors that may attenuate the effects of inflammation in younger ages is a critical period to mitigate HIV-related disparities later in life. Cannabis use is a noteworthy modifiable factor for investigation, given the substantial evidence of its role in anti- inflammatory processes and its rapidly accelerating legal and social acceptance; however, the rigor of prior research examining the influence of cannabis on inflammation and other key biological processes is limited because studies have mostly been cross-sectional, used self-reported measures of cannabis use, and are not generalizable to young Black SMM with HIV. To address these gaps, this K23 proposal – Cannabis Use and Proximal Immune Dysregulation (CUPID) – will fortify my Career Development efforts to (1) understand how biomarkers of cannabis may influence inflammation and leukocyte telomere length and (2) examine the modifying role of multilevel sexual minority stress. This K23 proposal will chart a pathway to achieve my long- term Career Goals of becoming an R01-funded investigator with expertise in multilevel determinants of biobehavioral processes underpinning HIV-related health disparities to guide the development of interventions with Black SMM with HIV. To accomplish my career goals, I will need training (1) to develop a comprehensive understanding of biomarkers of cannabis use, inflammation, and leukocyte telomere length; (2) to advance my understanding of multilevel sexual minority stress assessment in Black SMM; and (3) to develop expertise in analyzing longitudinal data. An accomplished, interdisciplinary Mentorship Team committed to supporting my transition to an independent investigator will provide guidance on the training and research activities. Specific Aims are (1) to determine the relationship between cannabis use and biomarkers of inflammation and leukocyte telomere length; and (2) to evaluate whether individual- interpersonal- community- and societal level sexual minority stress moderate the relationship of cannabis with inflammation and leukocyte telomere length. CUPID will inform the development of an R01 proposal for a more definitive cohort study to further elucidate the bio- behavioral pathways whereby cannabis use, and sexual minority stress are linked to inflammation and leukocyte telomere length in Black SMM with HIV.

项目总结/摘要 背景黑人性少数男性（SMM）与非黑人男性相比， 西班牙裔白色男性，在生命过程的早期获得症状严重程度更高的年龄相关疾病， 死于艾滋病毒感染的比率更高。早期生活中的压力与关键的生物过程有关， 特别是炎症和较短的白细胞端粒长度，这与艾滋病毒相关 合并症和年龄相关疾病。据记载，年轻的黑人SMM经历了多层次的 性少数压力，如性别身份隐瞒，受害，和社区同性恋恐惧症- 耻辱的产物，使健康结果进一步复杂化。因此，了解可能削弱 炎症对年轻人的影响是减轻以后生活中与艾滋病毒有关的差异的关键时期。 大麻的使用是值得注意的调查可变因素，因为有大量证据表明其在反毒品方面的作用， 炎症过程及其迅速加速的法律的和社会接受;然而， 研究大麻对炎症和其他关键生物过程的影响是有限的 因为研究大多是横断面的，使用自我报告的大麻使用措施，而不是 可推广到年轻的黑人SMM与艾滋病毒。为了弥补这些差距，K23提案-大麻的使用和 近端免疫失调（丘比特）-将加强我的职业发展努力（1）了解如何 大麻的生物标志物可能影响炎症和白细胞端粒长度，以及（2）检查 多层次性少数压力的修正作用。这个K23提案将为实现我的长期目标开辟一条道路- 成为一名R 01资助的研究者，拥有多层次决定因素的专业知识， 支持艾滋病毒相关健康差异的生物行为过程，以指导干预措施的制定 黑SMM与艾滋病毒。为了实现我的职业目标，我需要接受培训， 了解大麻使用、炎症和白细胞端粒长度的生物标志物;（2）推进我的研究， 了解黑人SMM中的多层次性少数压力评估;（3）发展以下方面的专业知识 分析纵向数据。一个成功的，跨学科的导师团队致力于支持我的 过渡到独立调查员的工作将为培训和研究活动提供指导。具体 目的是（1）确定大麻使用与炎症和白细胞生物标志物之间的关系 端粒长度;和（2）评估是否个人-人际-社区-和社会层面的性行为 少数民族压力缓和大麻与炎症和白细胞端粒长度的关系。丘比特 将为R 01提案的制定提供信息，以便进行更明确的队列研究，进一步阐明生物- 大麻使用和性少数压力与炎症和白细胞相关的行为途径 携带HIV黑SMM中端粒长度。