用于检测乙醛-蛋白质加合物的酶测定法-猫眼课题宝

用于检测乙醛-蛋白质加合物的酶测定法

批准号：

10760201

负责人：

Kevin K Desai

金额：

$27.21万

依托单位：

REVEL PHARMACEUTICALS INC.

依托单位国家：

美国

项目类别：

财政年份：

2023

资助国家：

美国

项目状态：

已结题

起止时间：

2023-08-01 至 2024-07-31

来源：

https://reporter.nih.gov/project-details/10760201

关键词：

Acetaldehyde Active Sites Address Advanced Glycosylation End Products Alcohol abuse Alcohol consumption Alcoholic Liver Diseases Alcoholism Alcohols Amino Acids Applications Grants Biological Biological Assay Biological Markers Blood Glucose Bovine Serum Albumin Cattle Coupled DNA Data Detection Development Diabetes Mellitus Diagnosis Digestion Engineering Enzymes Escherichia coli Ethanol Metabolism Ethanol toxicity Evolution Excision FDA approved Generations Genes Glucose Glycosylated hemoglobin A Goals Health Hemoglobin Horseradish Peroxidase Hydrogen Peroxide Knowledge Libraries Liver Lysine Measures Methodology Methods Modeling Modification Mutagenesis Oxidases Patients Peptide Hydrolases Performance Pharmacologic Substance Plasmids Production Proteins Reaction Request for Applications Sampling Schiff Bases Severities Side Sorting Source Structure System Techniques Technology Testing Variant addiction adduct alcohol exposure alcohol use disorder chronic alcohol ingestion design detection assay ethyl lysine genetic selection glycation improved in vitro Assay member novel prototype rapid detection repaired response screening sugar tool

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ABSTRACT Chronic alcohol consumption is a significant issue worldwide which can lead to addiction and damage throughout the body. The first step in alcohol metabolism is its conversion into acetaldehyde, which is a highly reactive and toxic molecule. The formation of acetaldehyde adducts with protein and DNA is a primary mechanism of ethanol toxicity. Acetaldehyde adducts are a direct biomarker for alcohol abuse. We intend to develop a facile and rapid enzyme-based assay for measuring acetaldehyde-protein adducts to assess alcohol use and alcohol-related health consequences.

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