Patient-Oriented Research in Global Cardiovascular Diseases and Interactions with HIV

全球心血管疾病及其与艾滋病毒相互作用的以患者为导向的研究

• 批准号: 10762609
• 负责人: Robert N Peck
• 金额: $ 12.63万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10762609
• 关键词: AIDS prevention; Address; Adolescent; Adult; Africa; African; Ambulatory Care Facilities; Award; Biological Markers; Blood Pressure; Cardiovascular Diseases; Caring; Chronic Disease; Clinic; Clinical; Clinical Investigator; Clinical Trials; Cluster randomized trial; Communities; Community Health Aides; Development; Diagnosis; Diastolic heart failure; Disease; Echocardiography; Environment; Event; Eye; Faculty; Family; Fellowship; Foundations; Functional disorder; Funding; Galectin 3; Goals; Grant; Guidelines; HIV; Heart; Hospital Mortality; Hospitalization; Hospitals; Hybrids; Hypertension; Institution; Interdisciplinary Study; International; Intervention; Kenya; Kidney; Leadership; Learning; Life Style; Link; Low income; Medicine; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Modeling; Morbidity - disease rate; Myocardial dysfunction; Nursing Faculty; Organ; Patients; Persons; Pharmaceutical Preparations; Physicians; Plasma; Population; Prevention therapy; Privatization; Productivity; Proteins; Proteomics; Reference Standards; Religion; Research; Research Personnel; Research Project Grants; Research Training; Risk Factors; Role; Rural; Sampling; Schools; Scientist; Site; Sleep; Social Workers; Tanzania; Testing; Time; Training; Troponin I; Trust; United States; United States National Institutes of Health; biobank; biomarker identification; blood pressure elevation; blood pressure reduction; cardiovascular disorder epidemiology; cardiovascular disorder prevention; cardiovascular disorder risk; clinical implementation; cohort; community center; community engagement; cost; cost effective; design; empowerment; evidence base; experience; follow-up; health disparity; hypertension treatment; hypertensive; implementation science; implementation trial; implementation/effectiveness; improved; innovation; medical schools; member; mortality; novel; novel marker; patient oriented; patient oriented research; point of care; point of care testing; poor communities; poor sleep; predictive marker; prevent; pro-brain natriuretic peptide (1-76); research study; risk stratification; skills; training opportunity; young adult

ABSTRACT: The goals of this K24 application are for Dr. Robert Peck to train physician-scientists in the conduct of patient-oriented cardiovascular disease (CVD) research in East Africa, and to conduct a new study of novel biomarkers predicting the onset of diastolic dysfunction of the heart (Aim 1). The candidate has lived and conducted research in Tanzania for the past 15 years. He helped to establish a new medical college and developed longstanding partnerships with leading research organizations in Tanzania (MITU) and Kenya (KWTRP). These partnerships, with the ongoing research studies, provide him with an outstanding research environment to study CVD in the context of Africa while also training a cadre of young investigators. The training that he offers leverage 3 NIH R01 funded projects in Tanzania (Aims 2-4), foundation awards (Aim 5), and a newly funded CVD research project in Kenya (Aim 6). United States (US) trainees from Weill Cornell Medicine will be supported by NIH T32 training grants and spend ~50% of their time at research sites in East Africa, which have longstanding international collaborators and excellent research training environments. East African trainees will be supported by two NIH D43 training grants and institutional funds. The common theme is that all of the research projects have patient-oriented research on CVD as the focus, with an emphasis on interactions with HIV, and will serve as vehicles for mentored research training. The specific aims include: 1. Biomarkers for incident diastolic dysfunction in people living with HIV (PLWH) in Tanzania 2. HIV, sleep, nocturnal blood pressure, and CVD in Tanzania 3. A cluster randomized trial of engaging religious leaders to reduce blood pressure in Tanzania 4. Reducing post-hospital mortality related to severe hypertension in Tanzania 5. Causes and consequences of hypertension in adolescents in Tanzania 6. Point-of-care risk stratification for community-centered hypertension treatment in Kenya The focus of research training will be on a diverse pool of clinical trainees, ranging from residents to fellows to clinical faculty. The candidate has a strong track record of mentoring patient-oriented researchers in Tanzania and participates in multiple private and NIH sponsored research fellowships at Weill Cornell. Trainees will participate in research projects in Tanzania (Aims 1-5) and also in Kenya (Aim 6). Trainees learn through the conduct of their mentored research project and partnerships with colleagues from the US and East Africa on related studies. The K24 award will enable the candidate to decrease his administrative responsibilities and commit at least 25% effort to CVD research mentorship of US and Tanzanian trainees. As part of the K24, he will pursue formal training in mentorship as well as strengthening his skills in translational biomarker research.

摘要：此K24应用程序的目标是为Robert Peck博士培训内科科学家 在东非开展面向患者的心血管疾病(CVD)研究，并进行一项新的研究 预测心脏舒张期功能障碍发病的新生物标志物(目标1)。这位候选人活了下来 并在坦桑尼亚进行了15年的研究。他帮助建立了一所新的医学院， 与坦桑尼亚(MITU)和肯尼亚的领先研究机构建立了长期合作伙伴关系 (KWTRP)。这些伙伴关系，加上正在进行的研究，为他提供了一项杰出的研究 在非洲的背景下研究心血管疾病的环境，同时还培训一批年轻的调查人员。这个 他提供的培训利用了3个由NIH R01资助的坦桑尼亚项目(AIMS 2-4)，基金会奖(AIM 5)， 以及一个新资助的肯尼亚心血管疾病研究项目(目标6)。来自威尔·康奈尔大学的美国(美国)学员 医学将得到NIH T32培训补助金的支持，他们将把大约50%的时间花在东部的研究地点 非洲拥有长期的国际合作者和良好的研究培训环境。东 非洲受训人员将得到两笔NIH D43培训赠款和机构基金的支持。共同的主题是 所有研究项目都以患者为中心的心血管疾病研究为重点，重点是 与艾滋病毒的相互作用，并将作为指导研究培训的工具。具体目标包括： 1.坦桑尼亚艾滋病毒携带者(PLWH)发生舒张期功能障碍的生物标志物 2.坦桑尼亚的艾滋病毒、睡眠、夜间血压和心血管疾病 3.坦桑尼亚一项关于宗教领袖参与降低血压的整群随机试验 4.降低坦桑尼亚与严重高血压有关的医院后死亡率 5.坦桑尼亚青少年高血压的原因和后果 6.肯尼亚以社区为中心的高血压治疗的护理点风险分层 研究培训的重点将放在不同的临床实习生身上，从住院医生到研究员，到 临床教员。这位候选人在坦桑尼亚指导以患者为导向的研究人员方面有着良好的记录 并参加了威尔·康奈尔大学的多项私人和国立卫生研究院赞助的研究奖学金。实习生将 参与坦桑尼亚(目标1-5)和肯尼亚(目标6)的研究项目。学员通过以下方式学习 指导他们的研究项目，并与来自美国和东非的同事建立伙伴关系 相关研究。K24奖励将使候选人能够减少他的行政责任和 投入至少25%的精力用于指导美国和坦桑尼亚学员的心血管疾病研究。作为K24的一部分，他 将在指导方面接受正式培训，并加强他在翻译生物标记物研究方面的技能。