Tech-GENA: Basic Multi-Media Genetics Education for Native Americans

描述(由申请者提供)：这个第一阶段SBIR项目的唯一具体目标是建立多媒体基础癌症遗传学教育干预的技术优势和可行性，该干预措施是互动的、引人入胜的，并且在文化上适合美洲原住民。该产品名为Tech-Gena，将是根据非常成功的社区验证的美洲原住民遗传教育(GENA(R))课程改编的基于网络和CD-ROM的产品。第一阶段的目标是：1)开发基于Gena(R)模块“什么是细胞”的交互式遗传教育原型干预；2)在美洲原住民社区中至少3个不同的地理/文化地区评估Tech-Gena(R)原型；以及3)评估目标人群对Tech-Gena(R)原型的满意度和接受度。该项目的总体目标是提供有关遗传学的准确信息，特别是与癌症有关的信息，以消除阻碍美洲原住民参与基因研究和基因测试的神话和错误信息。Tech-Gena产品的目标受众将是年轻的美洲原住民成年人。研究目标人群将包括32名18-55岁、几乎没有遗传教育背景的土著成年人，他们将参加评估Tech-Gena原型第一稿和第二稿的焦点小组。八位55岁的土著长老将通过线人采访来评估前两份草案。最后，4名18-25岁的年轻土著成年人和4名与土著学生一起工作的教育工作者将对原型的第三稿进行评估。除了关于如何改进原型草稿的问题外，参与者还将被问及测试前后的知识和态度问题，以确定原型是否对这些参数有影响。教育工作者将被问及是否会使用最终的Tech-Gena产品，以及他们的机构可能会为此支付多少钱。标准的统计方法将被用来分析测试前后在知识和态度上的差异。将使用定性数据分析来确定参与者答复中存在的主题。第一阶段项目将以部分互动的网络和光盘为基础的原型草案结束。将编写一份全面的报告，并起草一份技术指南大纲。癌症是一种遗传性疾病，一个人对遗传学的了解越多，他对癌症的了解也就越多。不幸的是，关于基因研究和测试的神话和错误信息在社区和个人层面上成为了障碍，使许多美洲原住民无法参与这种研究和测试。事实上，许多部落根本不允许在他们的部落社区内进行基因研究。Tech-Gena产品的目的是提供有关人类细胞和遗传学的基本、准确的信息，以及它们与癌症的关系，目的是纠正存在的错误信息。交互式多媒体Tech-Gena产品将有助于为美洲原住民提供必要的知识，以便在参与遗传学研究和测试方面做出明智的选择。

DESCRIPTION (provided by applicant): The single Specific Aim of this Phase I SBIR project is to establish the technical merit and feasibility of developing a multimedia basic cancer genetics education intervention that is interactive, engaging, and culturally appropriate for Native Americans. The product is called Tech-GENA, and is to be a Web and CD- ROM-based adaptation of the highly successful, community-validated Genetic Education for Native Americans (GENA(R)) curriculum. The Phase I objectives are: 1) Develop an interactive genetic education prototype intervention based on GENA(R) module "What is a cell;" 2) Evaluate the Tech-GENA(R) prototype in at least 3 diverse geographic/cultural regions in Native American communities; and 3) Evaluate the target populations' satisfaction with and acceptance of the Tech-GENA(R) prototypes. The overall goal of the project is to provide accurate information about genetics, especially as it relates to cancer, in order to dispel myths and misinformation that have served as barriers to the participation of Native Americans in genetic research and genetic testing. The target audience for the Tech-GENA product will be young Native American adults. The study target population will include 32 Native adults 18-55 years of age with little to no genetic education background who will take part in focus groups evaluating the 1st and 2nd draft of Tech-GENA prototype. Eight Native elders >55 years of age will evaluate the first two drafts through Informant Interviews. Finally, 4 young Native adults 18 - 25 years of age and 4 educators who work with Native students will evaluate the 3rd draft of the prototype. In addition to questions about how the prototype drafts can be improved, participants will be asked pre and post-test knowledge and attitude questions to determine if the prototype has an effect on these parameters. Educators will be asked if they would use the final Tech-GENA product and how much their institution is likely to pay for it. Standard statistical methods will be used to analyze differences in knowledge and attitude between pre and post-tests. Qualitative data analysis will be used to identify themes present in the participant responses. The Phase I project will end with a final partially interactive web and CD-ROM based prototype draft. A comprehensive report will be generated and a technical guide outline will be drafted. PUBLIC HEALTH RELEVANCE Cancer is a genetic disease with the more a person understands genetics, the more that person will understand cancer. Unfortunately, myths and misinformation about genetic research and testing have served as barriers at the community and individual level keeping many Native Americans from participating in this kind of research and testing. In fact, many tribes do not allow genetic research within their tribal communities at all. The purpose of the Tech-GENA product is to provide basic, accurate information about the human cell and genetics and how they relate to cancer with the goal of correcting the false information that exists. The interactive multimedia Tech-GENA product will help provide the necessary knowledge for Native Americans to make informed choices about participating in genetics research and testing.