Electron Spin Resonance Microanalyzer

描述（由申请方提供）：电子自旋共振光谱法是一种广泛用于检测自由基和顺磁中心的技术。有超过23，000篇已发表的生物医学研究论文引用了这项技术，特别是使用自旋标记和测量活性氧和活性氮。然而，电子自旋共振的应用也扩展到化学，生物化学，物理学，辐射测年，以及石油化学勘探和精炼，石油状况监测，食品灭菌和许多其他领域的商业应用。历史上，电子自旋共振光谱仪一直是非常大、非常昂贵的实验室设备，因此许多潜在用户不容易使用。所提出的是一个微型的，廉价的，高灵敏度的电子自旋共振光谱仪仪器，这将使这种强大的分析技术，以更广泛的用户范围的发展。 公共卫生相关性：自由基是许多疾病过程的重要贡献者。我们建议，使一个简单的，低成本的，便携式的自由基测量分析工具，特别是在临床和生物医学研究设置。

DESCRIPTION (provided by applicant): Electron spin resonance spectrometry is a widely used technique for the detection of free radicals and paramagnetic centers. There are over 23,000 published biomedical research papers citing this technique, particularly the use of spin labeling and measurement of reactive oxygen species and reactive nitrogen species. However, applications of electron spin resonance also extend into chemistry, biochemistry, physics, radiation dating, and commercial applications in petrochemical exploration and refining, oil condition monitoring, food sterilization and many other areas. Historically, electron spin resonance spectrometers have been very large, very expensive pieces of lab equipment that are therefore not readily accessible to many potential users. What is proposed is the development of a miniature, inexpensive, high sensitivity electron spin resonance spectrometer instrument that will make this powerful analytical technique accessible to a much broader range of users. PUBLIC HEALTH RELEVANCE: Free radicals are an important contributor to many disease processes. We propose to make a simple, low cost, portable analysis tool for the measurement of free radicals, particularly in clinical and biomedical research settings.