Metabolic regulation of ribosome biogenesis.

核糖体生物发生的代谢调节。

• 批准号: nhmrc : 1043890
• 负责人: Prof Michael Hall
• 金额: $ 37.06万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/metabolic-regulation-ribosome-biogenesis/111612
• 关键词: Metabolic; regulation; ribosome; biogenesis.

Mammalian cells have developed a complex signalling network responsible for monitoring and responding to changes in the levels of growth factors and the availability of nutrients, energy and oxygen in their environment. Deregulation of this network often results in uncontrolled cell growth and diseases including cardiac hypertrophy and cancer. This proposal aims to understand how this network controls cell growth and identify potential targets for diseases driven by uncontrolled growth.

哺乳动物细胞已经形成了一个复杂的信号网络，负责监测和响应生长因子水平的变化以及环境中营养物质、能量和氧气的可用性。该网络的放松管制通常会导致细胞生长失控和疾病，包括心脏肥大和癌症。该提案旨在了解该网络如何控制细胞生长，并确定由不受控制的生长驱动的疾病的潜在目标。