An Informatics Resource for Targeted Nanoparticle Therapeutics
An Informatics Resource for Targeted Nanoparticle Therapeutics
批准号:
7930500
负责人:
David Sept
金额:
$28.55万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
AffinityBehaviorBiodistributionCancer CenterCancer DiagnosticsCellsClassificationDataDatabasesDevelopmentDiagnosisDiagnosticDoctor of PhilosophyDrug Delivery SystemsDrug KineticsDrug toxicityDrug usageElementsFailureGoalsIn VitroInformation ResourcesKnowledgeLigand BindingModelingNanotechnologyOnline SystemsOntologyPharmaceutical PreparationsPharmacodynamicsPharmacologic SubstanceProcessPropertyResearch PersonnelResource InformaticsResourcesSideSimulateSiteSolutionsTechnologyTestingTherapeuticToxic effectWorkbasecancer Biomedical Informatics Gridcancer preventioncancer therapycomputer frameworkcross reactivityin vivonanoparticlenanoscalenanoscienceparticlepharmacodynamic modelpharmacokinetic modelsmall moleculetargeted deliverytooluptakeweb based interface
中文摘要
项目四:David Sept博士
英文摘要
Project IV - David Sept, Ph.D.
Title: An Informatics Resource for Targeted Nanoparticle Therapeutics
Each year, many billions of dollars are spent on the development and testing of new drugs for the treatment
of cancer. Although these compounds perform well in pre-trial in vitro screens, their failure in vivo is typically
attributed to problems with toxicity originating from misdistribution, cross-reactivity, or non-specific
accumulation at other sites. Targeted delivery of high affinity drugs using nanoparticles promises to alleviate
many of these difficulties; however, there are still many unknowns with respect to the physical and
pharmacological properties of such nanoscale therapeutics. The focus of this project is to develop a
nanoparticle informatics resource that will include a comprehensive taxonomical database of available
technologies and a toolbox for pharmacokinetics and pharmacodynamics modeling of nanoparticles. This
resource will be developed by a team of three computational biologists (Baker, Pappu, and Sept). It will
collate information relevant to the pharmacological behavior of these nanoparticles, including the uptake,
degradation and clearance of these particles, as well as the ability to conjugate each particle with binding
ligands and small molecules. Additionally, the resource will develop and apply both pharmacokinetics and
pharmacodynamics models to simulate the workings of targeted nanoparticles as drug delivery agents. By
providing a comprehensive and centralized resource for such information, this resource will allow
researchers from either the nanoscience or pharmaceutical side to find compatible technologies and
solutions that will enable their product to be used in the treatment, diagnosis or prevention of cancer. In this
manner, this project will directly facilitate the development of nanoparticle technologies; particularly those in
Projects I - III within this SCCNE proposal.
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会议论文
Dynamic Regulation of the Actin Filament Barbed End
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批准号:10369597
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项目类别:
-
资助金额:$29.93万
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财政年份:2020
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负责人:David Sept
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依托单位:
Dynamic Regulation of the Actin Filament Barbed End
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批准号:10590667
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项目类别:
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资助金额:$29.84万
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财政年份:2020
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负责人:David Sept
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依托单位:
An Informatics Resource for Targeted Nanoparticle Therapeutics
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批准号:7738080
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项目类别:
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资助金额:$19.44万
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财政年份:2008
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负责人:David Sept
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依托单位:
DYNAMICS AND ORGANIZATION OF THE CYTOSKELETON
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批准号:7181784
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项目类别:
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资助金额:$0.1万
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财政年份:2004
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负责人:David Sept
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依托单位:
Protein interactions underlying actin-based motility
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批准号:7101719
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项目类别:
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资助金额:$26.26万
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财政年份:2002
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负责人:David Sept
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依托单位:
Protein interactions underlying actin-based motility
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批准号:6577500
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项目类别:
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资助金额:$27.16万
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财政年份:2002
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负责人:David Sept
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依托单位:
Protein interactions underlying actin-based motility
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批准号:6780879
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项目类别:
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资助金额:$26.89万
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财政年份:2002
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负责人:David Sept
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依托单位:
Protein interactions underlying actin-based motility
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批准号:6927244
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项目类别:
-
资助金额:$26.89万
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财政年份:2002
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负责人:David Sept
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依托单位:
Protein interactions underlying actin-based motility
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批准号:6619499
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项目类别:
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资助金额:$26.89万
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财政年份:2002
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负责人:David Sept
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依托单位:
国内基金
海外基金
greenwashing behavior in China:Basedon an integrated view of reconfiguration of environmental authority and decoupling logic
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批准号:--
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项目类别:外国学者研究基金项目
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资助金额:--
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批准年份:2024
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负责人:YU BYUNGJUN
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依托单位:
Incentive and governance schenism study of corporate green washing behavior in China: Based on an integiated view of econfiguration of environmental authority and decoupling logic
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批准号:--
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项目类别:外国学者研究基金项目
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资助金额:--
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批准年份:2024
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负责人:YU BYUNGJUN
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依托单位: