Metabolism-driven interactions of non-typeable Haemophilus influenzae and its host: a critical factor in infection?

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Non-typeable Haemophilus influenzae (NTHi) is the underlying cause of many severe acute and chronic respiratory infections, which represent a significant burden to the healthcare system. As NTHi is unable to survive outside the human host, it is is highly adapted to survival in the body niches it colonizes. We are investigating how NTHI is able to survive in the presence of tissue inflammation, and whether it contributes to the inflammatory process through some of its metabolic products.