Metabolism-driven interactions of non-typeable Haemophilus influenzae and its host: a critical factor in infection?

不可分型流感嗜血杆菌及其宿主代谢驱动的相互作用：感染的关键因素？

• 批准号: nhmrc : 1043532
• 负责人: A/Pr Ulrike Kappler
• 金额: $ 31.67万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/metabolism-driven-interactions-factor-infection/111585
• 关键词: Metabolism; driven; interactions; non; typeable

Non-typeable Haemophilus influenzae (NTHi) is the underlying cause of many severe acute and chronic respiratory infections, which represent a significant burden to the healthcare system. As NTHi is unable to survive outside the human host, it is is highly adapted to survival in the body niches it colonizes. We are investigating how NTHI is able to survive in the presence of tissue inflammation, and whether it contributes to the inflammatory process through some of its metabolic products.

不可分型流感嗜血杆菌（NTHi）是许多严重急性和慢性呼吸道感染的根本原因，对卫生保健系统构成重大负担。由于NTHi无法在人类宿主之外生存，因此它高度适应于在其殖民的身体壁龛中生存。我们正在研究NTHI如何能够在组织炎症存在的情况下存活，以及它是否通过一些代谢产物参与炎症过程。