A NONHUMAN PRIMATE MODEL OF OBSTRUCTIVE RENAL DYSPLASIA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The objective of these studies is to investigate the prenatal pathogenesis of obstructive renal disease in a nonhuman primate model that parallels the disease observed in humans. An important feature of this model is the recapitulation of normal glomerular development and architecture, which is associated with significant podocyte apoptosis and is evident as early as the pre-vascularized S-shaped nephron.