Metformin and dietary advice to improve insulin sensitivity and promote Gestational Restriction of Weight in pregnant women who are obese: the GRoW randomised trial

肥胖是怀孕和分娩期间的一个重大健康问题，与有充分记录的风险有关。肥胖的妇女在胰岛素抵抗增加的状态下开始怀孕，代谢和炎症环境的改变提供了过量的营养，并刺激了胎儿的生长。GRoW随机试验的目的是评估二甲双胍和饮食建议改善肥胖孕妇胰岛素敏感性对健康结局的影响。

Obesity is a significant health issue during pregnancy and childbirth associated with well documented risks. Women who are obese commence pregnancy in a state of increased insulin resistance, the altered metabolic and inflammatory environment providing an excess of nutrients, and a stimulus to fetal growth. The aims of the GRoW randomised trial are to evaluate the effects of metformin and dietary advice to improve insulin sensitivity in obese pregnant women on health outcomes.