3rd US/EU Conference on Repair of Endogenous Genome Damage

描述(由申请者提供)：这份R13会议赠款提案请求部分支持第三届美国/欧盟会议，题为“修复内源性基因组损伤”。这一系列会议的广泛目标是促进来自美国和欧盟国家的科学家就内源性DNA损伤(主要是氧化)的处理方面的最新进展进行讨论，包括修复及其在癌症、其他病理生理和衰老中的作用。我们会议的一个重要目标是探讨合作努力，特别是在两大洲的年轻调查人员之间。该系列于2003年在弗吉尼亚州的一次会议上启动，取得了巨大成功。当时决定，这一系列会议将继续每隔一年举行一次，地点将在美国和欧盟国家之间切换。因此，第二次会议于2005年11月在西西里岛举行。由于不可避免的原因，原定于2007年举行的第三届美国/欧盟会议被推迟到2008年11月5日至9日，并将在德克萨斯州加尔维斯顿的穆迪花园会议中心举行。德克萨斯大学加尔维斯顿分校是得克萨斯州历史最悠久的医学院，将是本次会议的共同赞助商。这次为期4天的会议将有100多名与会者参加，其中包括45名特邀演讲者和会议主席，来自美国和欧盟的代表各占一半。特别强调邀请的演讲者和海报主持人中都有年轻的调查人员。其中一些海报将被选为简短的口头演示。将作出特别努力，让妇女和少数群体科学家作为发言者和其他参与者。 这次会议的重点与其他类似会议不同，因为它的焦点相当狭窄，关注的是内源性DNA损伤。这些损伤主要通过碱基切除和单链断裂修复(BER/SSBR)途径修复。BER/SSBR的多个亚通路已经进化为处理不同的损伤。此外，修复受到多种参数的调节，包括组织和细胞类型、细胞周期、细胞分化、基因组中病变的位置和染色质结构。将讨论自2005年会议以来在这些领域取得的新发现以及因修复不足而确定的疾病。最近的研究表明，BER互动组的存在，修复蛋白之间以协调的方式相互作用。核和线粒体基因组修复的年龄相关性变化也将包括在内。修复过程的全面描述应具有重大的翻译意义。最后，这次会议致力于讨论我们的认识现状，未来的方向和领导人面临的挑战，应该对维修领域的初级调查人员有利。

DESCRIPTION (provided by applicant): This R13 Conference grant proposal requests partial support for the 3rd US/EU Conference titled, "Repair of Endogenous Genome Damage". The broad objective of this Conference series is to promote discussion among scientists from US and EU countries about the recent advancements in processing of endogenous DNA damage (mostly oxidative) including repair and their role in cancer, other pathophysiologies and aging. An important objective of our meeting is exploration of collaborative efforts particularly among young investigators in two continents. The series was initiated with a meeting in Virginia in 2003 with great success. It was decided then that this conference series will continue to be held in alternate years and the venue will switch between a location in US and an EU country. Thus the 2nd conference was held in Sicily in November, 2005. For unavoidable reasons, the 3rd US/EU conference planned for 2007 was pushed back to November 5-9, 2008, and will be held in Moody Gardens Conference Center, Galveston, TX. The University of Texas Medical Branch in Galveston, the oldest medical school in Texas, will be a co-sponsor of this conference. The 4-day meeting will be attended by a little more than 100 participants including 45 invited speakers and session chairs, with equal representation from the US and EU. Special emphasis is placed on inclusion of young investigators both among invited speakers and poster presenters. Some of the posters will be selected for short oral presentation. Particular efforts will be made to include women and minority group scientists as speakers and other participants. The focus of this meeting is distinct from that of other, similar meetings because of its rather narrow focus on endogenous DNA damages. These damages are repaired primarily via the base excision and single- strand break repair (BER/SSBR) pathway. Multiple subpathways of BER/SSBR have evolved to process diverge damages. Furthermore, repair is regulated by multiple parameters, including tissue and cell types, cell cycle, cell differentiation, location of lesions in the genome and chromatin structures. New discoveries made in these areas and diseases due to repair deficiency identified since the meeting in 2005 will be discussed. Recent studies have suggested the existence of the BER interactome where the repair proteins interact with one another in a coordinated fashion. Age-dependent changes in repair of nuclear and mitochondrial genomes will also be covered. Comprehensive characterization of the repair processes should have significant translational implications. Finally, this conference devoted to discussion of the current state of our understanding, future directions and challenges by the leaders should be beneficial to the junior investigators in the repair field.