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Interleukin-10 in acute respiratory virus infection

Interleukin-10 in acute respiratory virus infection
白介素10在急性呼吸道病毒感染中的作用
批准号:
7746088
负责人:
Thomas J Braciale
金额:
$24.83万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-06-18 至 2014-05-31

项目摘要

项目成果

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中文摘要
翻译
肺部炎症和损伤是病毒感染的常见结果(在某些情况下甚至是致命的) 对呼吸道的影响。呼吸道病毒感染触发宿主先天和 适应性免疫系统。宿主响应对于病毒清除和恢复至关重要,但也是一种 伴随病毒清除而导致肺损伤的重要原因。最近的相关例子 人类感染SARS冠状病毒时是否观察到免疫介导的肺部炎症/损伤 以及H5N1禽流感病毒。项目1的长期目标是定义和描述 天然免疫系统中树突状细胞、单核/巨噬细胞、NK细胞之间的相互作用 和获得性免疫效应T淋巴细胞(Tej)在病毒清除和控制过程中的作用 呼吸道实验性病毒感染期间的炎症/损伤。 这一应用的基础是我们最近在A型小鼠模型中出人意料的发现 流感感染,抗病毒效应T细胞(包括CD4+Te和更突出的CDS+Te)渗透 在Te过程中,感染的肺产生高水平的抗炎/调节细胞因子IL-10 对感染和病毒清除的反应。此外,我们还发现阻断Te来源的IL-1的作用。 10感染期间会导致肺部炎症增加和致命性损伤。我们的证据进一步 提示这种Te来源的IL-10在控制肺部炎症/损伤水平中起核心作用 由单个核细胞渗入受感染的肺以应对病毒感染和促炎反应而产生 病毒免疫(Te)释放的介体。我们想要分析的是表达和调控 IL-10和特异性Te来源的IL-10在感染肺中的表达及该细胞因子对对照的影响 病毒清除和肺部炎症/损伤。项目1的目标是:1.评估细胞 IL-10的来源及其在流感病毒感染中的作用;2.分析IL-10的产生调节 确定病毒感染对Te来源的IL-2产生的影响。 10.拟议的研究旨在补充项目2、3和4中正在进行的相关研究。
英文摘要
Pulmonary inflammation and injury is a frequent (and, in some instances, lethal) outcome of virus infections of the respiratory tract. Respiratory virus infection triggers a coordinated response from the host innate and adaptive immune systems. The host response is essential for virus clearance and recovery, but is also a significant cause of pulmonary injury that can accompany virus elimination. Relevant recent examples of this are the immune-mediated lung inflammation/injury observed in human infections with the SARS coronavirus and the H5N1 avian influenza viruses. The long-term goal of Project 1 is to define and characterize the interactions between cells of the innate immune system i.e. dendritic cells, monocyte/ macrophage, NK cells and adaptive immune effector T lymphocytes (Tej in the process of virus clearance and in the control of inflammation/injury during experimental virus infection of the respiratory tract. The foundation for this application is our recent and unexpected findings in the murine model of type A influenza infection that anti-viral effector T-cells (both CD4 +Te and more prominently CDS +Te) infiltrating the infected lungs produce high levels of the anti-inflammatory/regulatory cytokines IL-10 during the Te response to infection and virus elimination. Furthermore, we found that blocking the effect of Te-derived IL- 10 during infection results in increased pulmonary inflammation and lethal injury. Our evidence further suggests that this Te-derived IL-10 plays a central role in controlling the level of lung inflammation/injury produced by mononuclear cells infiltrating the infected lungs in response to virus infection and the proinflammatory mediators released by virus- immune (Te). We wish to analyze the expression and regulation of IL-10 and specifically Te-derived IL-10 in the infected lungs and the impact of this cytokine on the control of virus clearance and lung inflammation/injury. The aims of Project 1 are: 1. To evaluate the cellular sources and effects of IL-10 on influenza virus infection; 2. To analyze the regulation of IL-10 production by Te during influenza infection; 3. To determine the impact of viral infection on the production of Te-derived IL- 10. The proposed studies are designed to complement ongoing related studies in Projects 2, 3 and 4.
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Leukotriene modifying agents in the prevention of excess morbidity and mortality from influenza
Leukotriene modifying agents in the prevention of excess morbidity and mortality from influenza
Adipokines in Pulmonary Viral Infection
  • 批准号:
    8974711
  • 项目类别:
  • 资助金额:
    $23.7万
  • 财政年份:
    2015
  • 负责人:
    Thomas J Braciale
  • 依托单位:
Adipokines in Pulmonary Viral Infection
  • 批准号:
    9089941
  • 项目类别:
  • 资助金额:
    $19.75万
  • 财政年份:
    2015
  • 负责人:
    Thomas J Braciale
  • 依托单位:
海外基金