New Opportunities: Quorum Sensing in Burkolderia mallei, a Novel Therapeutic Targ

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Bacterial quorum sensing involves small molecule ci among individual cells in a population. Quorum s< Burkholderia mallei holds a particular interest. First, III aeruginosa quorum sensing is involved in virulence quorum sensing inhibitors have been hindered by th infections. The availability of such models for fi. malle will eventually lead to tests of efficacy for small mole belief among scientists working on quorum sensing is discriminate between a host and a free-living state, fi no known environmental reservoir. Quorum sensing m types of infections by this pathogen. Finally, a most < anti-S. mallei therapeutic development. Dr. Greenber sensing reporter system for use in a high-throughput s at identification of quorum-controlled fi. mallei ge technology and require the construction of a quorum-j closely related fi. thailandensis. A new counter-sele thailandensis will be described, as will plans to extend mutations in members of the B. mallei group repres obstacle faced by fi. mallei biologists. 3ll-cell signaling that allows coordination of behavior snsing in the NIAID Category B Priority Pathogen <e for certain other pathogens such as Pseudomonas of fi. mallei. Efforts to develop anti-Pseucfomo/ias e lack of adequate animal models for Pseudomonas i affords us the ability to put a program in motion that cule inhibitors in animal models. Second, a common > that it allows a pathogen (or at least a symbiont) to jrkholderia mallei is an obligate animal pathogen with ust be involved in discrimination of different stages or Dbviously, quorum sensing in fi. ma//e/ is a target for g proposes to adapt his recently developed quorum creen for inhibitors. Further experiments will be aimed nes. These experiments will involve promoter-trap sensing regulator "gutted strain of fi. mallei and or the action method for insertional gene inactivation in fi. the procedure to fi. mallei. This method for generating >ents a major advance that will overcome a current