Bioinformatics and Genomics Core

生物信息学和基因组学核心

• 批准号: 7678842
• 负责人: Bruno Sobral
• 金额: $ 15.61万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7678842
• 关键词: Bioinformatics; Biological; Biology; Class; Computer software; DNA; Environment; Funding; Genomics; Information Management; Information Systems; Institutes; Laboratories; Measurement; Molecular; Organism; Performance; Research; Research Infrastructure; Research Project Grants; Resource Sharing; Sampling; Training; Virginia; data acquisition; laboratory facility; member; pathogen; programs; protein metabolite; research facility

The Virginia Bioinformatics Institute (VBI) at Virginia Tech proposes to serve as the Bioinformatics/Genomics Core Research Facility for the mid-Atlantic RCE. VBI was created by the Commonwealth of Virginia as a world-class bioinformatics research center and a shared resource and its research programs center on the ¿disease triangle¿, or host-pathogen-environment interactions. Thus, VBI is scientifically focused on pathosystems biology, through comprehensive quantitative measurements of molecular components of living systems. Specifically, to serve the genomics core component, VBI will provide high-performance laboratory infrastructure for analysis of biological samples with respect to DNA, RNA, proteins and metabolites via VBl¿s Core Laboratory Facility. To serve as the bioinformatics core, VBI will provide high-Performance computational and information management needs via VBl¿s Core Computational Facility and it will evolve, deploy and support VBl¿s software information system for PathoSystems Biology-called PafhPorf, a DOD-funded project-to enable data acquisition, storage, analysis, curation, and integration for the RCE members and beyond. Finally, VBI will train and educate RCE research project constituencies on computing and information systems use for their RCE research objectives.

弗吉尼亚理工大学的弗吉尼亚生物信息学研究所（VBI）提议作为 生物信息学/基因组学核心研究设施的中大西洋RCE。VBI是由 弗吉尼亚联邦作为世界级的生物信息学研究中心和共享资源， 研究项目的中心是“疾病三角”，即宿主-病原体-环境相互作用。因此，在本发明中， VBI通过全面的定量测量， 生命系统的分子组成部分。具体而言，为了服务于基因组学核心组件，VBI将 提供高性能的实验室基础设施，用于分析生物样品的DNA， RNA，蛋白质和代谢物通过VBl的核心实验室设施。作为生物信息学的核心， VBI将通过其核心提供高性能计算和信息管理需求 计算设施，它将发展，部署和支持VBl的软件信息系统， 病理系统生物学-称为PafhPorf，国防部资助的项目-使数据采集，存储， 为RCE成员及其他人提供分析、策展和整合。最后，VBI将培训和教育 RCE研究项目赞助者在RCE研究中使用计算和信息系统 目标.