Trial of Asthma Patient Education in the Emergency Room

描述（由申请人提供）：本研究的目标是将成功的哮喘教育计划转化为在急诊科 (ED) 接受治疗的患者。该提案是旨在改善哮喘患者预后的以患者为导向的临床研究轨迹的一部分。它建立在之前两项成功研究的基础上。第一项由罗伯特·伍德·约翰逊基金会 (Robert Wood Johnson Foundation) 支持，是一项针对 224 名成年初级保健患者的完整研究，该研究表明，患者自我效能感较低、抑郁症状较多以及对治疗的不切实际期望预示着生活质量会恶化，并且在 2 年内紧急资源利用率会增加。这些发现促成了一项正在进行的 NHLBI K23 随机对照试验，对 180 名成年初级保健哮喘患者实施多成分教育干预。该试验的初步结果表明，该干预措施可有效改善生活质量和紧急资源利用。因此，这项拟议的随机对照试验的具体目的是测试一种干预措施，以增强纽约市两间急诊室接受哮喘治疗的 296 名成年患者的知识、自我效能和哮喘相关的社会支持。干预措施将在急诊室（或收治患者的医院）进行一次面对面的会议，然后进行电话强化。主要结果将是从入组到 8 周期间患者内哮喘生活质量问卷总体评分的变化。第 8 周和第 16 周的其他结果将包括 β 受体激动剂的使用量、峰值流量、缺勤率、紧急资源利用和项目的成本效益。该程序的新颖特点是：易于管理；重点关注急需哮喘教育的急诊科患者；它还纳入了自我效能感，这是哮喘自我管理的一个重要方面，但尚未在 ED 项目中经过严格测试。长期目标是通过提供证据证明可以成功实施具有成本效益和临床有效的计划，在急诊室（哮喘教育服务不足的环境）中促进计划。其他长期目标是将该计划作为针对儿童、青少年及其在急诊室、初级保健和学校环境中的照顾者的类似计划的基础。

DESCRIPTION (provided by applicant): The goals of this study are to translate a successful asthma education program to patients who are treated in the emergency department (ED). This proposal is part of a trajectory of patient-oriented clinical research aimed at improving outcomes in asthma patients. It builds on two prior successful studies. The first, supported by the Robert Wood Johnson Foundation, is a completed study with 224 adult primary care patients that showed that less patient self-efficacy, more depressive symptoms, and unrealistic expectations of treatment predicted deterioration in quality of life and increased urgent resource utilization over 2 years. These findings led to an ongoing NHLBI K23 randomized controlled trial to implement a multi-component education intervention with 180 adult primary care asthma patients. Preliminary results from this trial indicate that this intervention is effective in improving quality of life and urgent resource utilization. Therefore, the specific aim of this proposed randomized controlled trial is to test an intervention to enhance knowledge, self-efficacy and asthma-related social support in 296 adult patients being treated for asthma in two EDs in New York City. The intervention will be administered during a single in-person session in the ED (or hospital for admitted patients) followed by telephone reinforcement. The primary outcome will be the within-patient change in overall Asthma Quality of Life Questionnaire scores from enrollment to 8 weeks. Additional outcomes at 8 and 16 weeks will be the amount of beta agonists used, peak flow rates, work absenteeism, urgent resource utilization, and cost-effectiveness of the program. The novel features of this program are: it is easy to administer; it focuses on ED patients who are in great need of asthma education; and it incorporates self-efficacy, an important aspect of asthma self-management that has not been rigorously tested in ED programs. The long-term objectives are to foster programs in the ED, a setting that has been underserved regarding asthma education, by providing evidence that cost-effective and clinically effective programs can be successfully implemented. Other long-term objectives are to use the program as a basis for similar programs for children, adolescents and their caregivers in the ED, primary care, and school settings.