Sun Protection Among Children with a Family History of Melanoma

有黑色素瘤家族史的儿童的防晒

• 批准号: 7617002
• 负责人: Beth A. Glenn
• 金额: $ 7.7万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7617002
• 关键词: 10 year old; Accounting; Age; Area; Attention; Attitude; California; Characteristics; Child; Childhood; Clinical Trials Design; Data; Development; Diagnosis; Disease; Education; Educational Background; Educational Status; Exposure to; Family; Family history of; Funding; Future; Goals; Group Practice; Incidence; Individual; Intervention; Intervention Studies; Intervention Trial; Interview; Life; Mails; Online Systems; Parents; Population; Prevention; Prevention Research; Protective Clothing; Public Health; Recording of previous events; Recruitment Activity; Research; Research Personnel; Risk; Risk Factors; Sample Size; Sampling; Scientist; Self Efficacy; Shapes; Skin Cancer; Stage at Diagnosis; Subgroup; Sun Exposure; Sunscreening Agents; Surveys; Telephone Interviews; Testing; The Sun; Time; Time Factors; UV Radiation Exposure; Ultraviolet Rays; Vulnerable Populations; Work; base; demographics; design; disorder risk; experience; health belief; high risk; melanoma; modifiable risk; neoplasm registry; response; sun protection; theories; therapy development; willingness

DESCRIPTION (provided by applicant): Exposure to ultraviolet radiation (UVR) is one of the primary modifiable risk factors for development of melanoma with exposures occurring early in life believed to be most critical. The relationship between UVR exposure and family history has not been well-studied; however, it is believed that the consequences of UVR among those already at increased risk due to family history may be significantly magnified. Still, very little research has targeted this high risk group and little is known about the sun protection practices of children in high risk families, who may be particularly vulnerable. This lack of information poses serious challenges for intervention development. Therefore, the goal of this exploratory study is to profile children with a parental history of melanoma in regards to their sun protection practices and obtain an understanding of the correlates of sun protection in this high risk and understudied group. Data obtained from this study will be critical for designing an intervention trial to increase sun protection practices for this group. Due to the complexity of collecting data directly from children, information about children will be collected from parents. We will use the California Cancer Registry to obtain the contact information for a random sample of melanoma cases between the ages of 25-50 years. Data will be collected from 200 cases with children between 5-10 years of age. Surveys will focus primarily on soliciting information from parents about their children's sun protection practices and assessing potential determinants of these practices including immutable factors (e.g., demographics, objective risk of the child to develop melanoma based on physical characteristics), mutable factors (e.g., parental health beliefs and attitudes), and factors specific to children at increased risk for melanoma that have not been previously examined (e.g., time since parent's diagnosis, parent's stage at diagnosis). Analyses will aim to 1) profile the sample with regards to current sun protection practices 2) evaluate theory and empirically-based hypotheses with regard to the contribution of immutable, melanoma-specific and mutable factors in the prediction of children's sun protection practices and 3) inform the practical aspects of intervention trial design including sample size calculations and recruitment estimates. Factors determined to be important correlates of sun protection in high risk children will be used to customize messages for the future intervention. In addition, this project will allow a new investigator, Dr. Glenn, to expand her research into a new area, melanoma prevention that is particularly important in California. The data collected in this project will be critical in preparing her to apply for R01 level funding and will help her on the path towards being an independent researcher.

描述（由申请人提供）：暴露于紫外线辐射 (UVR) 是发生黑色素瘤的主要可改变危险因素之一，其中生命早期发生的暴露被认为是最关键的。紫外线照射与家族史之间的关系尚未得到充分研究；然而，人们认为，对于那些因家族史而已经处于高风险的人来说，紫外线辐射的后果可能会显着放大。尽管如此，针对这一高风险群体的研究仍然很少，而且对于高风险家庭中儿童的防晒措施知之甚少，他们可能特别容易受到伤害。信息的缺乏给干预措施的发展带来了严峻的挑战。因此，这项探索性研究的目标是对有黑色素瘤父母史的儿童的防晒实践进行分析，并了解这一高风险和研究不足的群体中防晒的相关性。从这项研究中获得的数据对于设计干预试验以增加该群体的防晒实践至关重要。由于直接从儿童那里收集数据的复杂性，有关儿童的信息将从父母那里收集。我们将使用加州癌症登记处来获取年龄在 25 至 50 岁之间的黑色素瘤病例随机样本的联系信息。数据将从 200 个 5 至 10 岁儿童的病例中收集。调查将主要集中于向家长征求有关其孩子防晒做法的信息，并评估这些做法的潜在决定因素，包括不变因素（例如，人口统计、基于身体特征的儿童患黑色素瘤的客观风险）、可变因素（例如，父母的健康信念和态度）以及先前未检查过的黑色素瘤风险增加儿童特有的因素（例如，父母诊断后的时间、父母所处的阶段） 诊断时）。分析的目的是：1) 根据当前防晒实践对样本进行分析；2) 评估关于不可改变、黑色素瘤特异性和可变因素在预测儿童防晒实践中的贡献的理论和基于经验的假设；3) 为干预试验设计的实际方面提供信息，包括样本量计算和招募估计。确定为高危儿童防晒的重要相关因素将用于为未来的干预定制信息。此外，该项目还将允许新的研究人员格伦博士将她的研究扩展到一个新领域，即黑色素瘤预防，这在加利福尼亚州尤为重要。该项目中收集的数据对于她申请 R01 级资助至关重要，并将帮助她走上成为一名独立研究员的道路。