Impact of overdose prevention education and intranasal naloxone on fatal and non-

过量预防教育和鼻内纳洛酮对致命和非致命的影响

• 批准号: 7764847
• 负责人: Alexander Yale Walley
• 金额: $ 17.5万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7764847
• 关键词: Impact; overdose; prevention; education; intranasal

DESCRIPTION (provided by applicant): Project Summary/ Abstract Proposed Objective: As an evaluation of a state-sponsored overdose education and naloxone distribution (OEND) program, this research proposal, the INPEDE OD - Intranasal Naloxone and Prevention EDucation's Effect on OverDose - Study, responds to two research objectives of NCIPC/CDC RFA-CE-09-004: Unintentional poisoning from prescription drug overdoses in adults. First, the study will evaluate a program that provides naloxone as an antidote to persons at high risk for overdose (Research Objective #5). Second, it is research that can inform the ongoing policy debate on prescription drug overdose prevention through secondary data analysis in a state that will assess the health impact of a state's new overdose prevention program (Research Objective #7). Importance: Findings from this study will contribute to the scientific base for public health agencies and community organizations who are seeking novel approaches to address unintentional poisonings from drug overdose. Because the study is conducted in partnership with the Massachusetts Department of Public Health (MDPH) and it evaluates an MDPH-supported OEND program, this study will have direct and immediate impact on the implementation of this program in Massachusetts. Study Objectives: Specific Aim: Determine the impact of opioid overdose education with intranasal naloxone distribution (OEND) programs on fatal and non-fatal opioid overdose rates. Hypotheses: 1. Among Massachusetts communities with high burdens of fatal opioid overdose, the implementation of OEND programs from 2006 to 2009 is associated with decreased rates of fatal opioid overdose. 2. Among Massachusetts communities with high burdens of non-fatal opioid overdose, the implementation of OEND programs from 2006 to 2009 is associated with decreased rates of non-fatal opioid overdose. Study Design: Quasi-experimental interrupted time series comparison. Setting: Commonwealth of Massachusetts Participants: 18 communities in Massachusetts with 5 or more fatal opioid overdoses annually. Intervention: Massachusetts OEND program that includes distribution of intranasal naloxone among potential overdose bystanders, including needle exchange participants, clients of HIV/AIDS education and prevention programs, clients of substance abuse treatment programs, friends and family of people at high risk for overdose, and professionals working in substance abuse treatment and social services organizations. Outcome Measures: Change in annual fatal and non-fatal opioid overdose rates in communities in the Commonwealth of Massachusetts with high burden of opioid overdose. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE One novel approach to opioid overdose prevention is overdose education with naloxone distribution (OEND) programs. Among 18 Massachusetts communities with high numbers of opioid overdoses, the proposed INPEDE OD - Intranasal Naloxone and Prevention EDucation's Effect on OverDose - Study will determine the impact of OEND programs using an interrupted time series analysis to examine changes in annual fatal and non-fatal overdose rates over the period from 2002 and 2009 in those communities where an OEND program was implemented compared to those communities where it was not. The results of this study will be directly relevant to the overdose reduction efforts of public health entities nationwide.

描述(由申请人提供)： 项目摘要/摘要 建议目的：作为对国家支持的过量教育和纳洛酮分配(OEND)计划的评估，这项研究建议INPEDE OD-鼻腔纳洛酮和预防教育对过量研究的影响，响应了NCIPC/CDC RFA-CE-09-004的两个研究目标：成人处方药过量引起的意外中毒。首先，这项研究将评估一项计划，该计划为过量用药的高危人群提供纳洛酮解毒剂(研究目标5)。其次，这项研究可以通过二次数据分析为正在进行的关于处方药过量预防的政策辩论提供信息，该州将评估一个州新的过量药物预防计划对健康的影响(研究目标#7)。重要：这项研究的发现将为公共卫生机构和社区组织提供科学基础，他们正在寻找新的方法来解决药物过量造成的意外中毒问题。由于这项研究是与马萨诸塞州公共卫生部(MDPH)合作进行的，而且它评估了MDPH支持的OEND计划，因此这项研究将对该计划在马萨诸塞州的实施产生直接和立竿见影的影响。研究目的：明确阿片类药物过量教育与鼻内纳洛酮分配(OEND)计划对致命性和非致命性阿片类药物过量发生率的影响。假设：1.在致命性阿片类药物过量负担较高的马萨诸塞州社区中，2006年至2009年实施OEND计划与致命性阿片类药物过量发生率的下降有关。2.在马萨诸塞州非致命性阿片类药物过量负担较高的社区中，2006年至2009年实施的OEND方案与非致命性阿片类药物过量使用率的下降有关。研究设计：准实验间断时间序列比较。地点：马萨诸塞州联邦参与者：马萨诸塞州18个社区，每年有5次或5次以上致命的阿片类药物过量。干预：马萨诸塞州OEND计划，包括在潜在的过量旁观者中分发鼻内纳洛酮，这些旁观者包括针头交换参与者、艾滋病毒/艾滋病教育和预防计划的客户、药物滥用治疗计划的客户、过量服药高危人群的朋友和家人，以及在药物滥用治疗和社会服务组织工作的专业人员。观察指标：马萨诸塞州联邦阿片类药物过量负担高的社区每年致命性和非致命性阿片类药物过量比率的变化。 公共卫生相关性： 项目简介预防阿片类药物过量的一个新方法是纳洛酮分配(OEND)计划的过量教育。在阿片类药物过量数量较多的18个马萨诸塞州社区中，拟议的INPEDE OD-鼻腔纳洛酮和预防教育对过量服药的影响研究将使用中断的时间序列分析来确定OEND计划的影响，以检查那些实施了OEND计划的社区与没有实施OEND计划的社区在2002年至2009年期间每年致命和非致命过量服药率的变化。这项研究的结果将与全国公共卫生实体减少过量的努力直接相关。