The Genetic Determinants of Interstitial Lung Disease

间质性肺病的遗传决定因素

• 批准号: 7594016
• 负责人: David Schwartz
• 金额: $ 38.88万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7594016
• 关键词: Candidate Disease Gene; Collection; Coupled; DNA; DNA Resequencing; Development; Diagnostic; Disease; Disease Progression; Environmental Exposure; Etiology; Family; Gene Expression; Gene Expression Profiling; Genes; Genetic; Genetic Determinism; Genetic Risk; Genotype; Hamman-Rich syndrome; Interstitial Lung Diseases; Interstitial Pneumonia; Intervention; Molecular; Nonspecific Interstitial Pneumonia; Pathogenesis; Patients; Play; Predisposition; Pulmonary Fibrosis; Role; Staging; Susceptibility Gene; Transcript; Variant; Widespread Disease; human disease

The interstitial lung disease project seeks to uncover the genetic and environmental determinants of interstitial lung disease (ILD). Our ongoing effort to establish human disease/environmental exposure DNA collections, coupled with high-throughput resequencing, high-throughput genotyping, gene expression analysis by means of microarray, and Serial Analysis of Gene E Expression (SAGE) will allow us to explore relationships between specific environmental exposures and candidate susceptibility genes. In the past year we have moved closer to the identification of specific candidate genes responsible for susceptibility to ILD.

间质性肺疾病项目旨在揭示间质性肺疾病（ILD）的遗传和环境决定因素。我们正在努力建立人类疾病/环境暴露DNA收集，加上高通量重测序、高通量基因分型、基因表达分析（微阵列）和基因E表达序列分析（SAGE），将使我们能够探索特定环境暴露与候选易感基因之间的关系。在过去的一年里，我们已经接近确定ILD易感性的特定候选基因。