The Genetic Determinants of Interstitial Lung Disease

间质性肺病项目旨在揭示间质性肺病（ILD）的遗传和环境决定因素。我们正在努力建立人类疾病/环境暴露DNA收集，再加上高通量重测序，高通量基因分型，通过微阵列进行基因表达分析，以及基因E表达系列分析（SAGE）将使我们能够探索特定环境暴露和候选易感基因之间的关系。在过去的一年中，我们已经接近确定负责ILD易感性的特定候选基因。

The interstitial lung disease project seeks to uncover the genetic and environmental determinants of interstitial lung disease (ILD). Our ongoing effort to establish human disease/environmental exposure DNA collections, coupled with high-throughput resequencing, high-throughput genotyping, gene expression analysis by means of microarray, and Serial Analysis of Gene E Expression (SAGE) will allow us to explore relationships between specific environmental exposures and candidate susceptibility genes. In the past year we have moved closer to the identification of specific candidate genes responsible for susceptibility to ILD.