Nitrite as a Source of Bioactive Nitric Oxide

亚硝酸盐作为生物活性一氧化氮的来源

• 批准号: 7594422
• 负责人: RICHARD D CANNON
• 金额: $ 25.21万
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7594422
• 关键词: Accounting; Atherosclerosis; Authorization documentation; Blood; Blood Circulation; Blood Vessels; Cardiovascular system; Cell-Matrix Junction; Chest Pain; Clinical; Condition; Consent; Coronary; Coronary Arteriosclerosis; Diabetes Mellitus; Diet; Dilator; Drops; Elements; Eligibility Determination; Endothelium; Enrollment; Environment; Erythrocytes; Estrogens; Exercise stress test; Forearm; Functional disorder; Gases; Guanylate Cyclase; Hypertension; Inflammatory; Measurement; Meat; Nitrate Reductases; Nitrates; Nitric Oxide; Nitrites; Patients; Platelet Activation; Proteins; Protocols documentation; Reaction; Reporting; Research Ethics Committees; Source; Stomach; Surveys; Symptoms; Testing; Vascular Smooth Muscle; Vasodilator Agents; Vegetables; adduct; cell growth; cigarette smoking; design; dietary nitrate; hypercholesterolemia; nitrate; nitrate reductase; oral bacteria; oxidation; vasoconstriction

Protocol Progress: 34 patients met eligibility criteria for this protocol and were consented. There have been two drop-outs from the study; one because of unwillingness to continue with diet and the second because of chest pain on the morning of testing, reported to the IRB as an SAE (both reported at the 2005 continuing review). In all others, compliance with diet was highly satisfactory and measurements were performed as stipulated in the protocol. Reasons for Continuation of Protocol: We have permission to enroll 42 patients into this protocol in order to achieve 36 analyzable studies and we expect to achieve full enrollment during the coming year. The hypothesis posed in this study remains important, as the determination of dietary sources of NO may have important implications in the management of patients with atherosclerotic cardiovascular disease.

方案进展：34例患者符合本方案的合格性标准并获得知情同意。研究中有2例脱落; 1例是因为不愿意继续饮食，另1例是因为检测当天早晨胸痛，作为SAE报告给IRB（均在2005年持续审查时报告）。在所有其他研究中，饮食依从性非常令人满意，并按照方案规定进行测量。 继续研究方案的原因：我们已获准入组42例患者进入本方案，以完成36项可分析研究，我们预计在未来一年内完成全部入组。在这项研究中提出的假设仍然很重要，因为NO的饮食来源的确定可能有重要的意义，在动脉粥样硬化性心血管疾病患者的管理。