Clefts/Craniofacial Anomalies and Cancer Susceptibility

描述(申请人提供)：应聘者：雷纳托·梅内塞斯博士是一名牙医，目前正在匹兹堡大学口腔生物学系牙医学院接受博士后培训。他之前的研究重点是研究与人类颌骨骨质丢失相关的基因和与口腔裂隙相关的基因。他的短期目标是获得颅面和牙齿遗传疾病的基础知识，特别强调了解口腔裂的病因学、流行病学和表型。另一个短期目标是获得统计遗传学方面的专业知识。对口腔裂隙和统计遗传学有更深入的了解，对于发展他的独立研究生涯所需的能力至关重要。他的长期目标是成为一名独立的、跨学科的研究科学家，拥有一个由资金资助的研究项目，该项目将汇集遗传学、分子生物学和统计学的专业知识，以促进我们对颅面和牙齿遗传疾病等复杂特征的理解。环境：颅面和牙齿遗传学中心正在进行由NIDCR资助的研究颅面和牙齿疾病的赠款。匹兹堡大学在为博士后研究员和研究助理提供特殊的研究和职业发展培训方面有着长期的记录。导师和顾问：Alexandre Vieira博士和Mary Marazita博士将担任该奖项的导师。维埃拉博士是与牙齿畸形相关的口腔裂隙基因分析的资助人。他在颅面和牙齿遗传疾病方面拥有专业知识。玛丽·马拉齐塔博士是一位统计遗传学和口腔面部研究的专家，是几项颅面和牙齿遗传学补助金的私人投资者。癌症流行病学专家伊曼纽拉·泰奥利博士将担任顾问。研究职业发展计划：除了在他们的专业领域与导师一起进行一系列的辅导外，PI还将参加相关的研讨会、研讨会和社会会议。候选人的进步将由他的导师和一个外部委员会来评估。他的进步也将通过他设计、执行和撰写关于他的研究领域的论文的能力来评估。主要目标是能够在该奖项的最后一年申请R01赠款。研究研究：该项目的目的是确定可能导致颅面/牙齿异常和癌症的基因，并有助于更好地了解复杂的颅面和牙齿遗传疾病。

DESCRIPTION (provided by applicant): Candidate: Dr. Renato Menezes is a dentist currently undergoing postdoctoral training at the University of Pittsburgh, School of Dental Medicine, Department of Oral Biology. His prior research focuses on investigation of genes related to bone loss in the human jaws and genes associated with oral clefts. His short-term goal is to gain fundamental knowledge of craniofacial and dental genetic disorders, with special emphasis on understanding the etiology, epidemiology and phenotypes of oral clefts. Another short-term goal is to gain expertise in statistical genetics. A deeper understanding of oral clefts and statistical genetics is critical to the development of abilities necessary for his independent research career. His long term goal is to become an independent, interdisciplinary research scientist with a funded research program that will bring together expertise in genetics, molecular biology and statistics to advance our understanding of complex traits like craniofacial and dental genetic disorders. Environment: The Center for Craniofacial and Dental Genetics has ongoing NIDCR-funded grants examining craniofacial and dental disorders. The University of Pittsburgh has a long standing track record of providing postdoctoral fellows and research associates with exceptional research and career development training. Mentors & Consultants: Dr. Alexandre Vieira and Dr. Mary Marazita will serve as mentors for this award. Dr. Vieira is the PI on a grant for the genetic analysis of oral clefts in association with dental abnormalities. He has expertise in craniofacial and dental genetic disorders. Dr. Mary Marazita, an expert in statistical genetics and orafacial research is the PI on several craniofacial and dental genetics grants. Dr. Emanuela Taioli an expert in cancer epidemiology will serve as a consultant. Research Career Development Plan: In addition to a series of tutorials conducted with the mentors in their areas of expertise, the PI will also participate in relevant workshops, seminars, and society meetings. The progress of the candidate will be evaluated by his mentors and an external committee. His progress will also be evaluated through his ability to desing, execute and write his papers about his research area. The major goal is to be able to apply for a R01 grant during the last year of this award. Research Study: The aim of this project is to identify genes that can contribute to both craniofacial/dental anomalies and cancer, and contribute to the better understanding of complex craniofacial and dental genetic disorders.