Computational modeling of hemodynamics in cerebral aneurysms

描述(由申请人提供)：该项目旨在开发新的模拟能力，以阐明颅内动脉瘤的血流动力学。该项目的成功完成将创建一种系统和方法来确定颅内动脉瘤的功能，并将为临床医生制定治疗这些疾病的策略提供重要的新指导。因此，这些项目的具体目标是：1)确定CFD模型规范中的实验不精确性对计算速度场的影响；2)开发预测腔内血栓沉积区域的CFD建模能力；3)开始对多种患者特定的脑动脉瘤几何形状中的流动进行数值模拟，并开始研究血流动力学描述符在动脉瘤进展中的作用。目前医学成像和计算方法的进步为在特定患者的基础上使用数值模拟来研究颅内动脉瘤内的血流提供了机会。我们建议将最先进的医学成像与3D可视化和计算流体动力学方法相结合，以准确地捕捉流动物理及其对动脉瘤进展的影响。本项目的目的是开发一种计算流体力学工具，用于估计活体动脉瘤血管内的速度场，并确定该工具的有效范围。与公众健康相关：这项提案旨在开发评估脑动脉瘤内血流模式的计算方法。这些进展将提供所需的工具，以确定与血流相关的力量对动脉瘤疾病进展的影响。它们还将提供预测不同手术干预的可能结果的能力，并将为临床医生提供确定治疗这些疾病的最有效策略的能力。模拟颅内动脉瘤中血流模式的能力应该能为导致一些动脉瘤保持稳定、另一些动脉瘤生长、导致严重症状或破裂的潜在生理学提供新的见解，并极有可能造成毁灭性的脑损伤或死亡。

DESCRIPTION (provided by applicant): This project is aimed at developing new simulation capabilities for elucidating the hemodynamics in intracranial aneurysms. Successful completion of this project will create a systematic and methodical approach to the determination of function in intracranial aneurysms and will provide important new guidance to clinicians as they develop strategies to treat these disorders. The specific aims of these projects are therefore: 1) To determine the impact of experimental imprecision in the specification of CFD models on the computed velocity fields 2) To develop CFD modeling capabilities for predicting regions of intra-luminal thrombus deposition 3) To initiate numerical simulations of flow in a number of patient-specific cerebral aneurysm geometries and initiate a study of the role of hemodynamic descriptors in aneurysm progression. Current advances in medical imaging and computational methods provide an opportunity to use numerical modeling for investigation of the flow in intracranial aneurysms on a patient-specific basis. We propose to combine the state of the art medical imaging with 3D visualization and computational fluid dynamics methods to accurately capture the flow physics and its implications on the aneurysm progression. The objective of this project is to develop a CFD tool for estimating the velocity field in aneurysmal vessels in vivo, and to establish the range of validity of that tool. Relevance to public health: This proposal aims to develop computational methods for assessing blood flow patterns within cerebral aneurysms. These developments will provide the tools needed to determine the impact of flow-related forces to the progression of aneurysmal disease. They will also provide the ability to predict the likely outcome of different surgical interventions, and will provide clinicians with the ability to determine the most effective strategy for treating these disorders. The ability to simulate blood flow patterns in intracranial aneurysms should provide new insights into the underlying physiology that causes some aneurysms to remain stable, and others to grow, resulting in profound symptoms or rupture with a high likelihood of devastating cerebral injury or death.