Midcareer Investigator Award

描述（由申请人提供）：这个中期职业研究者奖申请寻求支持，为Matthew Smith博士提供受保护的时间，致力于以患者为导向的研究，并作为临床研究员和初级教师的有效研究导师。候选人是马萨诸塞州总医院泌尿生殖系统肿瘤临床研究主任和哈佛癌症中心（DF/HCC）Dana-Farber泌尿生殖系统肿瘤临床研究的联合主任。他的临床研究项目主要集中在癌症生存率，骨转移的预防和治疗，以及晚期前列腺癌的新疗法。他在以病人为导向的研究、独立的同行评审资金和成功的指导方面有着良好的记录。该申请的时间与候选人以患者为导向的研究计划的新方向，其他成功的资助申请，最近选择的新学员以及计划扩大的指导活动相吻合。 该申请的广泛的长期目标是推进以患者为导向的研究计划和候选人的指导活动。 具体目标是： 1.降低癌症幸存者的疾病和治疗相关发病率，治疗和预防骨转移，并开发晚期前列腺癌的新疗法。 2.评估前列腺癌幸存者中治疗相关的糖尿病和心血管疾病的机制，这是候选人以患者为导向的研究计划的新方向。 3.指导新的研究人员进行以患者为导向的研究。 这项研究计划可能会通过开发新的策略来治疗前列腺癌和预防骨转移来促进公共卫生，骨转移是前列腺癌发病的主要原因。此外，这项研究计划可能有助于减轻前列腺癌幸存者的癌症治疗负担。

DESCRIPTION (provided by applicant): This Midcareer Investigator Award application seeks support to provide Dr. Matthew Smith with protected time to devote to patient-oriented research and to act as an effective research mentor for clinical fellows and junior faculty. The candidate is the Clinical Research Director in Genitourinary Oncology at Massachusetts General Hospital and Co-Director of the Clinical Research in Genitourinary Malignancies for Dana-Farber Harvard Cancer Center (DF/HCC). His clinical research program focuses on cancer survivorship, prevention and treatment of bone metastases, and novel therapies for advanced prostate cancer. He has a strong record of patient-oriented research, independent peer-reviewed funding, and successful mentoring. The timing of this application coincides with the new directions in the candidate's patient-oriented research program, additional successful grant applications, recent selection of a new trainee, and the planned expansion of mentoring activities. The broad long-term objective of this application is to advance both the patient-oriented research program and mentoring activities of the candidate. The Specific Aims are: 1. To decrease disease and treatment-related morbidity in cancer survivors, to treat and prevent bone metastases, and to develop novel therapies for advanced prostate cancer. 2. To evaluate mechanism(s) of treatment-related diabetes and cardiovascular disease in prostate cancer survivors, a new direction in the candidate's patient-oriented research program. 3. To mentor new investigators in patient-oriented research. This research program may advance public health by developing new strategies to treat prostate cancer and to prevent bone metastases, a major cause of prostate cancer morbidity. In addition, this research program may help decrease the burden of cancer treatment for prostate cancer survivors.