ACTG 362: AZITHROMYCIN PROPHYLAXIS FOR PRIMARY PREVENTION OF MAC IN AIDS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a randomized placebo-controlled study to determine the efficacy of Azithromycin for primary prevention of Mycobacterium Avium Complex (MAC) and other infections in subjects who have acheived an increase in CD4 cells (from < 50 to >100 cells/mm3) on antiretroviral therapy. Subjects may not have had a prior diagnosis of MAC and will receive 1200 mg of Azithromycin once a week. The primary endpoint is to compare the time to development of MAC. There are numerous secondary objectives and several substudies evaluating azithromycin's effect on other bacterial infections common in the HIV+ patient.